Trading Arrangements, by Individual Trading Arrangements, by Individual [Table] Trading Arrangement: Trading Arrangement [Axis] Issuance of common stock for services Stock Issued During Period, Value, Issued for Services Non-cash interest expense related to the sale of future royalties Increase (Decrease) To Deferred Royalty Obligation, Non-Cash Interest Expense Related To Sale Of Future Royalties Increase (Decrease) To Deferred Royalty Obligation, Non-Cash Interest Expense Related To Sale Of Future Royalties Title of 12(b) Security Title of 12(b) Security Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-Sale [Table] Document Fiscal Year Focus Document Fiscal Year Focus Effective interest rate Contract With Customer, Liability, Amortization, Effective Interest Rate, Percent Contract With Customer, Liability, Amortization, Effective Interest Rate, Percent Term B Loan Term Loan 2022 B [Member] Term Loan 2022 B Adjustment to Compensation, Amount Adjustment to Compensation Amount Financial Instrument [Axis] Financial Instrument [Axis] Number of RSUs (in thousands) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Product supply delivered Contract With Customer, Liability, Revenue Recognized Cash Not Received, Current Contract With Customer, Liability, Revenue Recognized Cash Not Received, Current (in thousands) Current Change In Contract With Customer Liability, Current, Rollforward [Roll Forward] Change In Contract With Customer Liability, Current, Rollforward Knight Knight Therapeutics Inc [Member] Represents information pertaining to Knight Therapeutics Inc. Customer [Axis] Customer [Axis] Segment Reporting [Abstract] Common stock, $0.0001 par value per share; 500,000,000 shares authorized; 251,030,827 and 244,351,501 shares issued and outstanding as of September 30, 2026 and December 31, 2025, respectively Common Stock, Value, Issued 2027 Lessee, Operating Lease, Liability, to be Paid, Year One Accrued compensation and benefits Employee-related Liabilities, Current Schedule of Long-Term Debt Instruments Schedule of Long-Term Debt Instruments [Table Text Block] CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS Cash, Cash Equivalent, and Short-Term Investment [Text Block] Restatement Determination Date Restatement Determination Date Short-term investments Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract] Issuance of common stock upon vesting of restricted stock units (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Amendment Flag Amendment Flag Current liabilities Liabilities, Current [Abstract] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Inventory, non-current Inventory, non-current Inventory, Noncurrent Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Loss Contingencies [Table] Loss Contingencies [Table] Term G Loan Term Loan 2022 G [Member] Term Loan 2022 G Kyowa Kirin License Agreement Development Commercialization Distribution In Japan [Member] Agreement for the development, commercialization and distribution of tenapanor in Japan. The 2017 KKC Agreement. Leases [Abstract] Leases [Abstract] Commission on sale of stock per agreement (as percent) Stock Issuance Cost, Commission, Percent Stock Issuance Cost, Commission, Percent Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Entity Address, State or Province Entity Address, State or Province Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross PEO Total Compensation Amount PEO Total Compensation Amount (in thousands) Non-current Change In Contract With Customer Liability, Noncurrent, Rollforward [Roll Forward] Change In Contract With Customer Liability, Noncurrent, Rollforward Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Axis] Assets Assets, Fair Value Disclosure [Abstract] Healthcare royalty partners IV, L.P HealthCare Royalty Partners IV, L.P [Member] HealthCare Royalty Partners IV, L.P Cash and Cash Equivalents [Abstract] Cash and Cash Equivalents [Abstract] Unvested restricted stock units, beginning balance (in shares) Unvested restricted stock units, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Shares used in computing net loss per share - basic (in shares) Weighted average common shares outstanding - basic (in shares) Weighted Average Number of Shares Outstanding, Basic Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount Schedule of Noncurrent Inventory Schedule of Inventory, Noncurrent [Table Text Block] Contingencies [Line Items] Loss Contingencies [Line Items] Arrangements and Non-arrangement Transactions [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Additional details Lessee, Operating Lease, Description [Abstract] Number of reportable segments Number of Reportable Segments Total current liabilities Liabilities, Current Prepaid commercial manufacturing Increase (Decrease) In Prepaid Commercial Manufacturing Expense Increase (Decrease) In Prepaid Commercial Manufacturing Expense Deferred revenue Increase (Decrease) in Deferred Revenue Adjustments to principal value Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net [Abstract] Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Lease costs Lease, Cost [Abstract] Entity Address, City or Town Entity Address, City or Town Fosun Pharma License Agreement Development Commercialization Distribution In China [Member] Agreement for the development, commercialization and distribution of tenapanor in China. The Fosun Agreement. Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Advance Royalties [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Title and Position [Domain] Title and Position [Domain] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Vested (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Product sales, net Product [Member] Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Selling Selling Expense Adjusted Selling Expense Adjusted Proceeds from ESPP Proceeds from Stock Plans Level 2 Fair Value, Inputs, Level 2 [Member] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Licensing revenue License License [Member] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Schedule of Long-term Debt Instruments [Table] Schedule of Long-Term Debt Instruments [Table] Subsidiary or Equity Method Investee, Sale of Stock, Type [Table] Subsidiary or Equity Method Investee, Sale of Stock, Type [Table] Fosun Pharma Shanghai Fosun Pharmaceutical Industrial Development [Member] Represents Shanghai Fosun Pharmaceutical Industrial Development. Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Litigation Case [Axis] Litigation Case [Axis] Prepaid commercial manufacturing Prepaid Commercial Manufacturing, Current Prepaid Commercial Manufacturing, Current Schedule of Information Regarding Operating Segment Segment Reporting [Table Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Less Segment Reporting, Reconciliation [Abstract] Debt Instrument, Redemption, Period Two Debt Instrument, Redemption, Period Two [Member] Total long-term debt Long-Term Debt Reclassify amounts to be recognized in the next 12 months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Schedule of Undiscounted Cash Payment Obligations for Operating Lease Liabilities Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block] Supplemental disclosure of non-cash activities Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Document Period End Date Document Period End Date Changes in operating assets and liabilities Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Net cash used in investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Royalty and commercialization milestone payments remitted to HCR Increase (Decrease) To Deferred Royalty Obligation, Royalty And Commercialization Milestone Payments Remitted Increase (Decrease) To Deferred Royalty Obligation, Royalty And Commercialization Milestone Payments Remitted Term loan face amount Debt Instrument, Face Amount 2028 Lessee, Operating Lease, Liability, to be Paid, Year Two STOCKHOLDERS’ EQUITY Equity [Text Block] Security Exchange Name Security Exchange Name Prepaid product supply Contract With Customer, Liability, Revenue Invoiced As Prepayments For Product Supply, Noncurrent Contract With Customer, Liability, Revenue Invoiced As Prepayments For Product Supply, Noncurrent Granted (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Cardinal Health, Inc. Cardinal Health, Inc [Member] Cardinal Health, Inc Deferred royalty obligation related to the sale of future royalties Deferred royalty obligation balance as of January 1, Deferred royalty obligation balance as of September 30, Deferred Royalty Obligation, Noncurrent Deferred Royalty Obligation, Noncurrent Term D Loan Term Loan 2022 D [Member] Term Loan 2022 D Accumulated other comprehensive (loss) income Accumulated Other Comprehensive Income (Loss), Net of Tax Entity Shell Company Entity Shell Company Cash and cash equivalents Cash and Cash Equivalent [Abstract] Current portion of operating lease liability Current portion of lease liabilities Less: Current portion of operating lease liability Operating Lease, Liability, Current Issuance of common stock for services (in shares) Stock Issued During Period, Shares, Issued for Services NET LOSS PER SHARE Earnings Per Share [Text Block] Name Outstanding Recovery, Individual Name Earnings Per Share [Abstract] Earnings Per Share [Abstract] Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] Document Fiscal Period Focus Document Fiscal Period Focus Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Total liabilities Liabilities Trading Symbol Trading Symbol Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member] Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Schedule of Total Unrecognized Stock-Based Compensation Expense, Net of Estimated Forfeitures Share-Based Payment Arrangement, Nonvested Award, Cost [Table Text Block] Company Selected Measure Name Company Selected Measure Name Sale of Stock [Domain] Sale of Stock [Domain] Total cash, cash equivalents and investments, Gross Unrealized Losses Cash Cash Equivalents And Investments Gross Unrealized Losses Cash, cash equivalents and investments gross unrealized losses. 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cash, cash equivalents and investments, Gross Unrealized Gains Cash Cash Equivalents And Investments Gross Unrealized Gains Cash, cash equivalents and investments gross unrealized gains. 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Attributable to Parent Other income, net Nonoperating Income (Expense) Assets Assets [Abstract] Title Trading Arrangement, Individual Title Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Accreted value of final fee Debt Instrument, Fee Amount Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Total operating lease liabilities Operating Lease, Liability Insider Trading Policies and Procedures [Line Items] Outstanding balance, beginning (in shares) Outstanding balance, ending (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Caremark, LLC Caremark, LLC [Member] Caremark, LLC Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Open Market Sales Agreement 2025, At The Market Offering Open Market Sales Agreement 2025, At The Market Offering [Member] Open Market Sales Agreement 2025, At The Market Offering Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Selling, general and administrative Selling, General and Administrative Expense COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Antidilutive securities excluded from computation of earnings per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Number of operating segments Number of segments Number of Operating Segments RSU grants Restricted stock units Restricted Stock Units (RSUs) [Member] Schedule of Anti-Dilutive Securities Not Considered in Diluted Net Loss Per Common Share Calculation Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Entity Central Index Key Entity Central Index Key Additional paid-in capital Additional Paid in Capital, Common Stock All Adjustments to Compensation All Adjustments to Compensation [Member] Other, net Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Other Item Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member] Net cash used in operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Income Statement [Abstract] Income Statement [Abstract] Stockholders’ equity Equity, Attributable to Parent [Abstract] Issuance of common stock under employee stock purchase plan (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Document Transition Report Document Transition Report Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Costs and operating expenses Operating Expenses [Abstract] Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Term Loan 2022 F And G Term Loan 2022 F And G [Member] Term Loan 2022 F And G Number of Shares (in thousands) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Floating per annum rate (as percent) Debt Instrument, Basis Spread on Variable Rate City Area Code City Area Code Debt Instrument, Redemption, Period One Debt Instrument, Redemption, Period One [Member] Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] All Individuals All Individuals [Member] Non-cash lease expense Operating Lease, Right-of-Use Asset, Periodic Reduction Name Forgone Recovery, Individual Name Average Remaining Vesting Period (in years) Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Non-GAAP Measure Description Non-GAAP Measure 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Investments And Cash, Amortized Cost Schedule of Additional Details of Leases Schedule Of Additional Details Of Leases [Table Text Block] The tabular disclosure of additional details of the leases. 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The Knight Agreement. INVENTORY Inventory Disclosure [Text Block] Issuance of common stock upon exercise of options Stock Issued During Period, Value, Stock Options Exercised Equity Awards Adjustments, Footnote Equity Awards Adjustments, Footnote [Text Block] Underlying Securities Award Underlying Securities Amount Purchases of investments Payments to Acquire Short-Term Investments REVENUE Revenue from Contract with Customer [Text Block] Forfeited or cancelled (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Proceeds from issuance of common stock under equity incentive plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Inventory Increase (Decrease) in Inventories Weighted-average discount rate Operating Lease, Weighted Average Discount Rate, Percent Segment Reporting [Table] Segment Reporting [Table] Issuance of common stock for services Stock Issued Title 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[Table] Fair Value, Recurring and Nonrecurring [Table] Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Maximum aggregate offering price Maximum Aggregate Offering Price Amount of maximum aggregate offering price. 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Ltd [Member] Represents the information pertaining to Kyowa Kirin Co., Ltd. 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Cencora, Inc. [Member] Cencora, Inc. 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