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Forfeited (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Increases due to amounts reclassified from non-current, to be recognized in the next twelve months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Allowance for credit loss on available-for-sale debt securities Debt Securities, Available-for-Sale, Allowance for Credit Loss Other Deferred Tax Assets, Other Entity Interactive Data Current Entity Interactive Data Current Knight Agreement License Agreement Development Commercialization Distribution In Canada [Member] Agreement for the development, commercialization and distribution fo tenapanor in Canada. The Knight Agreement. 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Term of payment of license fee, first installment Term Of Payment Of License Fee, First Installment Term of payment of first installment fee. Expected term (years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Contingencies [Line Items] Loss Contingencies [Line Items] Fair value analysis, percentage change in probability of occurrence Fair Value Sensitivity Analysis, Change In Probability Of Occurrence, Percentage Fair Value Sensitivity Analysis, Change In Probability Of Occurrence, Percentage 2014 Plan Two Thousand Fourteen Equity Incentive Award Plan [Member] 2014 Equity Incentive Award Plan [Member] Total of shares sold Equity Sales Agreement, Shares Issued Since Inception Equity Sales Agreement, Shares Issued Since Inception Arrangements and Non-arrangement Transactions [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Proceeds from milestone payments Revenue, Remaining Performance Obligation, Variable Consideration Amount Revenue, Remaining Performance Obligation, Variable Consideration Amount Number of payment tranches for fee receivable for reduction in royalty rate Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate, Number Of Payment Tranches Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate, Number Of Payment Tranches Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-Sale [Line Items] ICFR Auditor Attestation Flag ICFR Auditor Attestation Flag Number of separate collaborative agreements Number Of Separate Collaborative Agreements Number of separate collaborative agreements. Common stock, $0.0001 par value; 300,000,000 shares authorized; 198,575,016 and 130,182,535 shares issued and outstanding as of December 31, 2022 and December 31, 2021, respectively. 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Cash and cash equivalents at beginning of period Cash and cash equivalents at end of period Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents Deferred revenue - non-current Change In Contract With Customer Liability, Noncurrent, Rollforward [Roll Forward] Change In Contract With Customer Liability, Noncurrent, Rollforward Increases due to cash received, excluding amounts recognized as revenue during the period Contract With Customer, Liability, Increases Due To Cash Received, Excluding Amounts Recognized As Revenue During The Period Contract With Customer, Liability, Increases Due To Cash Received, Excluding Amounts Recognized As Revenue During The Period Schedule of Chargebacks, Discounts and Reserve Balances Schedule Of Gross To Net Sales Accruals [Table Text Block] Schedule Of Gross To Net Sales Accruals Loan Agreement Term loan Loans Payable [Member] Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Current liabilities: Liabilities, Current [Abstract] Term Loan A Term Loan 2022 A [Member] Term Loan 2022 A Exit fee, net product revenue threshold Loan Agreement, Exit Fee, Net Product Revenue Threshold Metric, Trailing Six Month Basis, Minimum Loan Agreement, Exit Fee, Net Product Revenue Threshold Metric, Trailing Six Month Basis, Minimum Proceeds from royalties received Proceeds from Royalties Received Common stock, shares issued (in shares) Common Stock, Shares, Issued 2022 Exit Fee addition at fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Purchases Increase due to unbilled prepayments recorded during the period Contract With Customer, Liability, Increase Due To Unbilled Prepayments Recorded Contract With Customer, Liability, Increase Due To Unbilled Prepayments Recorded Concentration Risk [Line Items] Concentration Risk [Line Items] Options vest and expected to vest (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Deferred revenue Beginning balance Ending balance Contract with Customer, Liability, Current 2017 KKC Agreement License Agreement Development Commercialization Distribution In Japan [Member] Agreement for the development, commercialization and distribution of tenapanor in Japan. The 2017 KKC Agreement. 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The 2019 KKC AGreement. 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Net loss per share of common stock - diluted (in dollars per share) Net loss per share - diluted (in dollars per share) Earnings Per Share, Diluted Shares available for grant, effect of granted (shares) Share-Based Compensation Arrangement By Share Based Payment Award, Number Of Shares Available For Grant, Decrease Due To Granted In Period Share-Based Compensation Arrangement By Share Based Payment Award, Number Of Shares Available For Grant, Decrease Due To Granted In Period Sale of Stock [Domain] Sale of Stock [Domain] Advance Royalties [Abstract] Proceeds from sale of property and equipment Proceeds from Sale of Property, Plant, and Equipment Amortization, effective interest rate, percent Contract With Customer, Liability, Amortization, Effective Interest Rate, Percent Contract With Customer, Liability, Amortization, Effective Interest Rate, Percent Vesting period (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Gain on disposition of property plant equipment Gain (Loss) on Disposition of Property Plant Equipment Stock-based compensation APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Schedule of Revenues from External Customers and Long-Lived Assets [Table] Schedule of Revenues from External Customers and Long-Lived Assets [Table] Loan agreement covenant, cash and cash equivalents as percentage of outstanding loan balance, minimum Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Minimum Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Minimum Prepaid commercial manufacturing Increase (Decrease) In Prepaid Commercial Manufacturing Expense Increase (Decrease) In Prepaid Commercial Manufacturing Expense Concentration Risk Type [Axis] Concentration Risk Type [Axis] Total current liabilities Liabilities, Current 2024 Lessee, Operating Lease, Liability, to be Paid, Year Two Customer Customer Concentration Risk [Member] Term Loan B Term Loan 2022 B [Member] Term Loan 2022 B Balance at beginning of year Balance at end of year Unrecognized Tax Benefits Deferred tax assets net of valuation allowance Deferred Tax Assets, Net of Valuation Allowance Components of the provision for income taxes Income Tax Expense (Benefit), Continuing Operations [Abstract] Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve [Line Items] Schedule of Restricted Stock Units Activity Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] Payment terms Revenue, General Payment Terms Revenue, General Payment Terms Issuance of common stock for services (in shares) Issuance of common stock for services (in shares) Stock Issued During Period, Shares, Issued for Services Payment to be received Revenue, Remaining Performance Obligation, Amount Corporate bonds Corporate Debt Securities [Member] Revenue Revenue from Contract with Customer Benchmark [Member] Summary of Undiscounted Cash Payment Obligations for Operating Lease Liabilities Lessee, Operating Lease, Liability, Maturity [Table Text Block] Entity Address, Address Line Two Entity Address, Address Line Two Entity Address, Address Line One Entity Address, Address Line One Income Tax Authority [Domain] Income Tax Authority [Domain] Cost of revenue Cost of Revenue Upfront payment Contract with Customer, Liability Total cash equivalents and investments, Cost Investments And Cash, Amortized Cost Investments And Cash, Amortized Cost Product and Service [Axis] Product and Service [Axis] Deferred tax liabilities: Deferred Tax Liabilities, Net [Abstract] Class of Stock [Domain] Class of Stock [Domain] Increase in valuation allowance Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] McKesson Corporation McKesson Corporation [Member] McKesson Corporation Go v. 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Cash and cash equivalents: Cash and Cash Equivalents, at Carrying Value [Abstract] 2022 Exit Fee Exit Fee 2022 [Member] Exit Fee 2022 Asset Class [Axis] Asset Class [Axis] Net Loss per Share Earnings Per Share, Policy [Policy Text Block] 2023 Long-Term Debt, Maturity, Year One Supplementary disclosure of non-cash activities: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Stock-based compensation Share-Based Payment Arrangement, Noncash Expense Schedule of Noncurrent Inventory Schedule of Inventory, Noncurrent [Table Text Block] Weighted-average grant-date estimated fair value of options granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Variable Rate [Axis] Variable Rate [Axis] Long-term debt, net of current portion Loans Payable, Noncurrent KKC Kkc [Member] Represents the information pertaining to KKC. Addition to floating per annum rate (percent) Debt Instrument, Variable Rate, Base Option Debt Instrument, Variable Rate, Base Option Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Research and development Research and development expenses Research and Development Expense [Member] Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Laboratory equipment Laboratory Equipment [Member] Laboratory Equipment [Member] Schedule of Computation of Net Loss Per Common Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Right-of-use assets obtained in exchange for lease obligations Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Derivatives and Hedging Activities Derivatives, Reporting of Derivative Activity [Policy Text Block] Maximum aggregate offering price Maximum Aggregate Offering Price Amount of maximum aggregate offering price. First installment of upfront license fees Collaboration And Licensing Agreements, Upfront License Fees, First Installment Collaboration And Licensing Agreements, Upfront License Fees, First Installment Customer [Domain] Customer [Domain]