Document And Entity Information Document Information [Table] Document Information [Line Items] Document Type Document Type Document Quarterly Report Document Quarterly Report Document Period End Date Document Period End Date Document Transition Report Document Transition Report Entity File Number Entity File Number Entity Registrant Name Entity Registrant Name Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line One Entity Address, City or Town Entity Address, City or Town Entity Address, State or Province Entity Address, State or Province Entity Address, Postal Zip Code Entity Address, Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Title of 12(b) Security Title of 12(b) Security Trading Symbol Trading Symbol Security Exchange Name Security Exchange Name Entity Current Reporting Status Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Amendment Flag Amendment Flag CONDENSED BALANCE SHEETS (Parenthetical) Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and cash equivalents Cash and cash equivalents, Amortized Cost Available-for-sale Securities, Debt Securities, Current Short-term investments Contract with Customer, Asset, Net, Current Unbilled revenue Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Operating Lease, Right-of-Use Asset Right-of-use assets Right-of-use assets Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation and benefits Contract with Customer, Liability, Current Uncharged license fees Operating Lease, Liability, Current Current portion of lease liabilities Current portion of operating lease liability Less: Loan payable, current portion Loan payable, current portion Deferred revenue Accrued Liabilities and Other Liabilities Accrued expenses and other current liabilities Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Operating lease liability, net of current portion Operating lease liability, net of current portion Loans Payable, Noncurrent Loan payable, net of current portion Liabilities Total liabilities Commitments and Contingencies Commitments and contingencies (Note 11) Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.0001 par value; 5,000,000 shares authorized; no shares issued and outstanding as of September 30, 2020 and December 31, 2019, respectively. Common Stock, Value, Issued Common stock, $0.0001 par value; 300,000,000 shares authorized; 90,243,409 and 88,817,741 shares issued and outstanding as of September 30, 2020 and December 31, 2019, respectively. Additional Paid in Capital, Common Stock Additional paid-in capital Retained Earnings (Accumulated Deficit) Accumulated deficit Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income Stockholders' Equity Attributable to Parent Balance, amount Balance, amount Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Statement [Table] Products and Services [Axis] Products And Services [Domain] Products and Services [Domain] License [Member] Licensing Collaborative Development [Member] Collaborative Development [Member] Collaborative development Represents the information pertaining to revenues from other product or services. Other Product Or Services Revenue [Member] Other Statement [Line Items] Revenues [Abstract] Revenues: Revenue from Contract with Customer, Excluding Assessed Tax Total revenues Revenue Operating Expenses [Abstract] Operating expenses: Cost of Revenue Cost of revenue Research and Development Expense Research and development General and Administrative Expense General and administrative Operating Expenses Total operating expenses Operating Income (Loss) Loss from operations Interest Expense Interest expense Nonoperating Income (Expense) Other income, net Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Loss before provision for income taxes Income Tax Expense (Benefit) Provision for income taxes Net Income (Loss) Attributable to Parent Net loss Net loss Earnings Per Share, Basic and Diluted Net loss per share - basic and diluted Net loss per common share, basic and diluted Weighted Average Number of Shares Outstanding, Basic and Diluted Weighted average common shares outstanding - basic and diluted Shares used in computing net loss per share - basic and diluted Comprehensive loss: Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Unrealized (losses) gains on available-for-sale securities Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss CONDENSED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid In Capital [Member] Additional Paid-In Capital Retained Earnings [Member] Accumulated Deficit Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive (Loss) Income Shares, Outstanding Balance, shares Balance, shares Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock under employee stock purchase plan, amount Proceeds Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock under employee stock purchase plan, shares Number of shares issued under ESPP Stock Issued During Period, Value, Issued for Services Issuance of common stock for services, amount Stock Issued During Period, Shares, Issued for Services Issuance of common stock for services, shares Issuance of common stock for services, shares Stock Issued During Period, Value, Stock Options Exercised Issuance of common stock upon exercise of options, amount Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Issuance of common stock upon exercise of options, shares Number of options exercised Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Number of shares issued upon vesting of restricted stock units Issuance of common stock upon vesting of restricted stock units, shares Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation CONDENSED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation Depreciation expense Amortization of Debt Issuance Costs Amortization of deferred financing costs Amortization of Deferred Charges Amortization of deferred compensation for services Accretion (Amortization) of Discounts and Premiums, Investments Amortization of premium on investment securities The amount of non cash lease expense. Non Cash Lease Expense Non-cash lease expense Share-based Compensation Stock-based compensation Increase (Decrease) in Derivative Liabilities Change in derivative liabilities Non-cash interest expense. Noncash Interest Expense Non-cash interest associated with debt discount accretion Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Amount of increase or decrease in unbilled revenue. Increase (Decrease) In Unbilled Revenue Unbilled revenue Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Employee Related Liabilities Accrued compensation and benefits Represents element information pertaining to increase decrease in operating lease liabilities. Increase Decrease in Operating Lease Liabilities Lease liabilities Increase (Decrease) in Accrued Liabilities Accrued and other liabilities Increase (Decrease) in Deferred Revenue Deferred revenue Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Investing activities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale Proceeds from maturities of investments Payments to Acquire Short-term Investments Purchases of investments Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash (used in) provided by investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Financing activities Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options Proceeds from issuance of common stock under stock plans Proceeds from issuance of common stock under equity incentive and stock purchase plans Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Cash and Cash Equivalents, Period Increase (Decrease) Net (decrease) increase in cash and cash equivalents Supplemental Cash Flow Information [Abstract] Supplementary disclosure of cash flow information: Income Taxes Paid, Net Income taxes paid Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Supplementary disclosure of non-cash activities: Right-of-use assets obtained in exchange for lease obligations Organization and Basis of Presentation Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Organization and Basis of Presentation Cash, Cash Equivalents and Short-Term Investments Cash, Cash Equivalents, and Short-term Investments [Text Block] Cash, Cash Equivalents and Short-Term Investments Fair Value Measurements Fair Value Disclosures [Text Block] Fair Value Measurements Derivative Liability Derivative Instruments And Hedging Activities Disclosure [Text Block] Derivative Liability Borrowing Debt Disclosure [Text Block] Borrowing Leases Lessee, Operating Leases [Text Block] Leases Equity Incentive Plans Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Equity Incentive Plans Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Stockholders' Equity Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share n/a Collaboration and Licensing Agreements Collaborative Arrangement Disclosure [Text Block] Collaboration and Licensing Agreements Contingencies Commitments and Contingencies Disclosure [Text Block] Contingencies Income Taxes Income Tax Disclosure [Text Block] Income Taxes Subsequent Events Subsequent Events [Text Block] Subsequent Events Summary of Significant Accounting Policies Basis of Accounting, Policy [Policy Text Block] Basis of Presentation Liquidity. Liquidity [Policy Text Block] Liquidity Use of Estimates, Policy [Policy Text Block] Use of Estimates New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Fair Value Measurement, Policy [Policy Text Block] Fair Value Measurements Cash, Cash Equivalents and Investments [Table Text Block] Schedule of Securities Classified as Cash, Cash Equivalents and Short-Term Investments Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Summary of Fair Value Measurements of Company's Financial Assets and Liabilities The tabular disclosure of changes in fair value of liability. Schedule of Changes in Fair Value [Table Text Block] Schedule of Changes in Fair Value Schedule of Maturities of Long-term Debt [Table Text Block] Schedule of Future Debt Payment Obligations The tabular disclosure of additional details of the leases. Schedule of Additional Details of Leases [Table Text Block] Summary of Additional Details of the Leases Lease, Cost [Table Text Block] Summary of Lease Costs Lessee, Operating Lease, Liability, Maturity [Table Text Block] Summary of Undiscounted Cash Payment Obligations for Operating Lease Liabilities Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Summary of Stock-Based Compensation Expense Recognized Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block] Summary of Total Unrecognized Stock-Based Compensation Expense, Net of Estimated Forfeitures Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Computation of Basic and Diluted Loss Per Share Attributable to Common Stockholders Contract with Customer, Asset and Liability [Table Text Block] Schedule of Changes in Deferred Revenue Number of Operating Segments Number of operating segments Schedule of Error Corrections and Prior Period Adjustment Restatement [Table] Error Corrections and Prior Period Adjustments Restatement [Line Items] Cash, cash equivalents and short term investments fair value disclosure. Cash Cash Equivalents And Short Term Investments Fair Value Disclosure Cash equivalents and short-term investments, Fair Value Cash and cash equivalents and short term investments. Cash Cash Equivalents And Short Term Investments [Table] Financial Instrument [Axis] Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Major Types of Debt and Equity Securities [Domain] Commercial Paper Not Included With Cash And Cash Equivalents [Member] Commercial Paper (Investments) [Member] Corporate Debt Securities [Member] Corporate Bonds (Investments) [Member] U S Government Corporations And Agencies Securities [Member] U.S. Government-Sponsored Agency Bonds [Member] Asset Backed Securities [Member] Asset-Backed Securities [Member] U S Treasury Notes Securities [Member] U.S. Treasury Notes [Member] Cash and Cash Equivalents [Axis] Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member] Cash and Cash Equivalents [Domain] Money Market Funds [Member] Money Market Funds [Member] Commercial Paper [Member] Commercial Paper (Cash Equivalents) [Member] Cash [Member] Cash [Member] Cash and cash equivalents and short term investments. Cash Cash Equivalents And Short Term Investments [Line Items] Other Cash Equivalents, at Carrying Value Cash and cash equivalents, Amortized Cost Cash and cash equivalents gross unrealized gains. Cash And Cash Equivalents Gross Unrealized Gains Cash and cash equivalents, Gross Unrealized Gains Cash and Cash Equivalents, Fair Value Disclosure Cash and cash equivalents, Fair Value Available-for-sale Securities, Amortized Cost Basis Short-term investments, Amortized Cost Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Short-term investments, Gross Unrealized Gains Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax Short-term investments, Gross Unrealized Losses Available-for-sale Securities Short-term investments, Fair Value Cash, Cash Equivalents, and Short-term Investments Cash equivalents and short-term investments, Amortized Cost Cash, cash equivalents and short term investments gross unrealized gains. Cash Cash Equivalents And Short Term Investments Gross Unrealized Gains Cash equivalents and short-term investments, Gross Unrealized Gains Cash, cash equivalents and short term investments gross unrealized losses. Cash Cash Equivalents And Short Term Investments Gross Unrealized Losses Cash equivalents and short-term investments, Gross Unrealized Losses Range [Axis] Range [Member] Range [Domain] Maximum [Member] Maximum Available-for-sale Securities, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Investment in continuous unrealized loss position for more than one year Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale Available-for-sale securities that were other-than-temporarily impaired Available for sale securities contractual maturity period. Available For Sale Securities Contractual Maturity Period Available for sale securities contractual maturity period Fair Value Measurements, Recurring and Nonrecurring [Table] Asset Class [Axis] Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Asset Class [Domain] Commercial Paper Cash Equivalents Including Securities [Member] Commercial Paper Cash Equivalents Including Securities [Member] Commercial Paper [Member] Domestic Corporate Debt Securities Including Cash Equivalents [Member] Domestic Corporate Debt Securities Including Cash Equivalents [Member] Corporate Bonds [Member] Liability Class [Axis] Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation By Liability Class [Domain] Fair Value by Liability Class [Domain] This represents information pertaining to derivative liability exit fees. Derivative Liability Exit Fee [Member] Derivative Liability Exit Fee [Member] Measurement Frequency [Axis] Fair Value Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value Measurements Recurring [Member] Fair Value, Recurring [Member] Fair Value, Hierarchy [Axis] Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value Inputs Level1 [Member] Level 1 [Member] Fair Value Inputs Level2 [Member] Level 2 [Member] Fair Value Inputs Level3 [Member] Level 3 [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Assets, Fair Value Disclosure [Abstract] Assets: Assets, Fair Value Disclosure Assets at fair value Liabilities: Financial and Nonfinancial Liabilities, Fair Value Disclosure Derivative liability Derivative [Table] Debt Instrument [Axis] Debt Instrument Name [Domain] Debt Instrument, Name [Domain] Represents the information pertaining to Solar Capital and Western Alliance Bank Loan Agreement. Solar Capital And Western Alliance Bank Loan Agreement [Member] Solar Capital and Western Alliance Bank Loan Agreement [Member] Derivative [Line Items] Business Exit Costs Exit Fee The reasonably possible percentage of the increase in the designated risk component used to determine the value of the financial instrument. Excludes defined benefit plan obligations. Percentage of Reasonably Possible Increase in Risk Assumption Percentage of increase in risk component The reasonably possible percentage of the decrease in the designated risk component used to determine the value of the financial instrument. Excludes defined benefit plan obligations. Percentage of Reasonably Possible Decrease in Risk Assumption Percentage decrease in risk component The increase (decrease) in a financial instrument as a result of an increase in a designated risk component that was reasonably possible at the end of the reporting period. Excludes defined benefit plan obligations. Increase (Decrease) in Financial Instrument Due to Reasonably Possible Increase in Designated Risk Component Fair value fluctuation due to increase in risk component The increase (decrease) in a financial instrument as a result of an decrease in a designated risk component that was reasonably possible at the end of the reporting period. Excludes defined benefit plan obligations. Increase (Decrease) in Financial Instrument Due to Reasonably Possible Decrease in Designated Risk Component Fair value fluctuation due to decrease in risk component Derivative Liability, Fair Value, Gross Liability Fair value of Exit Fee derivative liability at ending Fair value of Exit Fee derivative liability at beginning Unrealized Gain (Loss) on Derivatives Change in estimated fair value of derivative liability Schedule of Long-term Debt Instruments [Table] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] London Interbank Offered Rate L I B O R [Member] LIBOR Debt Instrument, Redemption, Period [Axis] Debt Instrument Redemption Period [Domain] Debt Instrument, Redemption, Period [Domain] This member represents redemption of debt at maturity date under the terms of the debt agreement. At Maturity [Member] At Maturity Debt Instrument Redemption Period One [Member] Prior to first anniversary of closing date Debt Instrument Redemption Period Two [Member] After first anniversary of closing date This member represents period of redemption of debt after second anniversary to maturity date under the terms of the debt agreement. After Second Anniversary To Maturity Date [Member] After second anniversary to maturity date Debt Instrument [Line Items] Term Loans Long-term Debt, Gross Amount of term loan facility Total repayment obligations Debt Instrument, Interest Rate, Stated Percentage Base interest rate Debt Instrument, Description of Variable Rate Basis Floating interest rate The percentage of premium payable on principal amount of the term loan at or before maturity redemption. Percentage of Premium Payable on Redemption of the Term Loan Percentage of premium payable on redemption of the term loan The amount of fee payable upon closing of the term loan. Fee Payable upon Closing of the Term Loan Amount of fee payable upon closing of the term loan The percentage of fee payable on prepayment of debt. Prepayment Fee Percentage Prepayment fee (as a percent) Percentage of additional default interest rate on the event of default. Default Interest Rate Additional default interest rate Long-term Debt, Fiscal Year Maturity [Abstract] Future debt payment obligations Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Less: Unamortized discount and debt issuance costs The unaccreted value of final fee of debt instrument. Debt Instrument, Unaccreted Value, Final Fee Less: Unaccreted value of final fee Long-term Debt Loan payable Assets and Liabilities, Lessee [Abstract] Additional details of the leases Operating Lease, Liability Total operating lease liabilities Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining life Operating Lease, Weighted Average Discount Rate, Percent Weighted-average discount rate Lease, Cost [Abstract] Facilities Operating Lease, Cost Operating lease expense Operating Lease, Payments Cash paid for operating lease Operating Lease Liabilities, Payments Due [Abstract] Undiscounted cash payment obligations for its operating lease liabilities Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year Remainder of 2020 Lessee, Operating Lease, Liability, Payments, Due Year Two 2021 Lessee, Operating Lease, Liability, Payments, Due Total undiscounted operating lease payments Lessee, Operating Lease, Liability, Undiscounted Excess Amount Imputed interest expenses Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Award Type [Axis] Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Equity Award [Domain] Employee Stock Option [Member] Options to Purchase Common Stock [Member] This member stands for performance-based restricted stock units. Performance Based Restricted Stock Units [Member] Performance-Based Restricted Stock Units (PRSUs) [Member] This member stands for time based restricted stock units. Time Based Restricted Stock Units [Member] Time Based Restricted Stock Units [Member] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Number of shares, granted Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted-average grant-date estimated fair value of options granted Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Number of shares, outstanding Allocated Share-based Compensation Expense Stock-based compensation expenses Share Price Purchase price Public offering price Share-based Compensation Arrangement by Share-based Payment Award, Options Outstanding, Weighted Average Exercise Price, and Additional Disclosures [Abstract] Share-Based Compensation Arrangement By Share-Based Payment Award Options Outstanding Weighted Average Exercise Price And Additional Disclosures [Abstract] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research And Development Expense [Member] Research and development General And Administrative Expense [Member] General and administrative Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized Compensation Expense Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Average Vesting Period Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Class of Stock [Axis] Class Of Stock [Domain] Class of Stock [Domain] Sale of Stock [Axis] Sale Of Stock Name Of Transaction [Domain] Sale of Stock [Domain] Represents information relating to At the market offering. At Market Offering [Member] AT The Market Offering [Member] Subsidiary, Sale of Stock [Line Items] Class of Warrant or Right, Number of Securities Called by Warrants or Rights Warrants sold and issued to purchase common stock Shares Issued, Price Per Share Purchase price of common shares Class of Warrant or Right, Exercise Price of Warrants or Rights Exercise price for warrants The period during which warrants can be exercised. Warrant Term Warrant exercise period Number of warrants (or share units) exercised during the current period. Warrants Exercised in Period Warrants exercised Amount of maximum aggregate offering price. Maximum Aggregate Offering Price Maximum aggregate offering price Total number of common shares of an entity that have been offered, issued or sold to shareholders. Common Stock, Shares, Offered, Issued or Sold Number of shares offered, issued or sold Net Income (Loss) Attributable to Parent [Abstract] Numerator: Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Denominator: Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Anti-dilutive securities not included in computation of diluted net loss per share attributable to common stockholders Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements And Nonarrangement Transactions [Member] Arrangements and Non-arrangement Transactions [Domain] Pertaining to the research collaboration and option agreement for research associated with identifying two pre-clinical compounds. The 2019 KKC AGreement. Research Collaboration And Option Agreement [Member] 2019 KKC Agreement Pertaining to license agreements. License Agreement [Member] License Agreement [Member] Agreement for the development, commercialization and distribution of tenapanor in Japan. The 2017 KKC Agreement. License Agreement Development Commercialization Distribution In Japan [Member] 2017 KKC Agreement Agreement to license certain specific patent and patent applications to XuanZhu. The XuanZhu Agreement. License Agreement Certain Specific Patent And Patent Applications [Member] XuanZhu Agreement Agreement for the development, commercialization and distribution of tenapanor in China. The Fosun Agreement. License Agreement Development Commercialization Distribution In China [Member] Fosun Agreement Agreement for the development, commercialization and distribution fo tenapanor in Canada. The Knight Agreement. License Agreement Development Commercialization Distribution In Canada [Member] Knight Agreement Information pertaining to development and commercialization member. Development And Commercialization [Member] Development and Commercialization Counterparty Name [Axis] Repurchase Agreement Counterparty Name [Domain] Counterparty Name [Domain] Represents the information pertaining to Kyowa Kirin Co., Ltd. Kyowa Kirin Co. Ltd [Member] Kyowa Kirin Co. Ltd Represents Shanghai Fosun Pharmaceutical Industrial Development. Shanghai Fosun Pharmaceutical Industrial Development [Member] Fosun Pharma Pertaining to XuanZhu (HK) Biopharmaceutical Limited. Xuanzhu H K Biopharmaceutical Limited [Member] XuanZhu Represents information pertaining to AstraZeneca. Astrazeneca [Member] Astra Zeneca Represents information pertaining to Knight Therapeutics Inc. Knight Therapeutics Inc [Member] Knight Minimum [Member] Minimum Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Number of pre-clinical study-ready compounds. Number Of Pre Clinical Study Ready Compounds Number of pre-clinical study-ready compounds Number of compounds inhibiting the first undisclosed target. Number Of Compound Inhibiting First Undisclosed Target Number of compounds inhibiting the first undisclosed target Number of development candidates. Number Of Development Candidates Number of development candidates Number of separate collaborative agreements. Number Of Separate Collaborative Agreements Number of separate collaborative agreements The amount of license fee recognized during the period. Collaboration And Licensing Agreements, Upfront Payment, Receivable Upfront payment recognized The amount of license fee receivable in first installment during the period. Collaboration And Licensing Agreements, Upfront Payment, Receivable, Fist Installment License fee receivable, first installment Term of payment of first installment fee. Term Of Payment Of License Fee, First Installment Term of payment of license fee, first installment The amount of license fee receivable in second installment during the period. Collaboration And Licensing Agreements, Upfront Payment, Receivable, Second Installment License fee receivable, Second instalment Term of agreement. Term Of Agreement Term of agreement The amount of initial transaction price. Collaboration And Licensing Agreements, Initial Transaction Price Initial transaction price Amount of change in estimate of revenue to be recognized during the period. Revenue From Contract With Customer Change In Estimate Change in estimates Transaction price allocated to partially unsatisfied performance obligations. Transaction Price Allocated To Partially Unsatisfied Performance Obligations Transaction price allocated to partially unsatisfied performance obligations Proceeds from License Fees Received Upfront payment received The amount of development milestones payment to be received under collaborative arrangements. Collaborative Arrangement Development Milestones Payment To Be Received Development milestones The amount of development milestone payment received to date. Collaborative Arrangement Development Milestones Payment Received Development milestones received The amount of commercialization milestones payment to be received under collaborative arrangements. Collaborative Arrangement Commercialization Milestones Payment To Be Received Commercialization milestones The amount of licenses fee recognized during the period. Collaboration And Licensing Agreements, License Fee License fee recognized The amount of second milestone payment recognized during the period. Collaboration And Licensing Agreements, Second Milestone Payment Second milestone payment Represents the amount of future development and commercialization milestone under collaborative arrangements. Collaborative Arrangement Future Development And Commercialization Milestones Future development milestones Represents the threshold percentage of net sales for tiered royalties. Threshold Percentage of Sales For Tiered Royalties Threshold percentage of net sales for tiered royalties Collaboration and licensing agreements, payment per termination agreement. Collaboration And Licensing Agreements, Payment Per Termination Agreement Payment per termination agreement Cost of revenue, aggregate amount recognized. Cost Of Revenue, Aggregate Amount Recognized Cost of revenue, aggregate amount recognized Represents the cash outflow from payments of uncharged license fees. Payments of Uncharged License Fees Cost of revenue, Amount Paid Represents percentage of royalty revenue. Percentage of Royalty Revenue Percentage of royalty revenue (as a percent) Represents percentage of non-royalty revenue. Percentage of non royalty revenue Percentage of non royalty revenue (as a percent) Contract with Customer, Liability Balance at September 30, 2020 Balance at December 31, 2019 Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received. Contract with Customer Liability Revenue Recognized Cash Received Decreases due to revenue recognized in the period for which cash has been received Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer is due. Contract with Customer Liability Revenue Recognized Cash Not Yet Received Decreases due to revenue recognized in the period for which cash has not been received Loss Contingency Accrual Contingent liabilities Subsequent Event [Table] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event [Member] Subsequent Event [Member] Subsequent Event [Line Items] Debt Instrument, Basis Spread on Variable Rate Floating interest rate (as a percent) Amount of amendment fee that the company has to pay to the lenders, under the debt instrument. Debt Instrument, Amendment Fee Amount Amendment fee