101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Consolidated Statements of Operations link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Consolidated Statements of Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) link:calculationLink link:presentationLink link:definitionLink 108 - Statement - Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 109 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Organization and Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Cash, Cash Equivalents and Investments link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Fair Value Measurements link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Property and Equipment link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Accrued and Other Liabilities link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Collaboration and Licensing Agreements link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Convertible Preferred Stock link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Preferred Stock Warrants link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Equity Incentive Plans link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Net Loss Per Share link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Related Party Transactions link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Selected Quarterly Financial Data (Unaudited) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Cash, Cash Equivalents and Investments (Tables) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Fair Value Measurements (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Property and Equipment (Tables) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Accrued and Other Liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Equity Incentive Plans (Tables) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Income Taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Net Loss Per Share (Tables) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Commitments and Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Selected Quarterly Financial Data (Unaudited) (Tables) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Organization and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Cash, Cash Equivalents and Investments - Schedule of Securities Classified as Cash and Cash Equivalents and Short-term Investments (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Cash, Cash Equivalents and Investments - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Fair Value Measurements - Summary of Fair Value Measurements of Company's Financial Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Property and Equipment - Summary of Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Property and Equipment - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Accrued and Other Liabilities - Schedule of Accrued Liabilities and Other Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Collaboration and Licensing Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Convertible Preferred Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Preferred Stock Warrants - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Equity Incentive Plans - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Equity Incentive Plans - Summary of Activity Under 2008 Plan, 2014 Plan and Inducement Plan Including Grants to Nonemployees Issued (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Equity Incentive Plans - Summary of Non-vested RSU Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Equity Incentive Plans - Summary of Weighted Average Assumptions to Estimate Fair value of Stock Option Awards and Employee Stock Purchase Plan (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - Disclosure - Equity Incentive Plans - Summary of Stock-Based Compensation Expense Recognized (Detail) link:calculationLink link:presentationLink link:definitionLink 153 - Disclosure - Income Taxes - Reconciliation of Statutory Federal Income Tax Rate to the Company's Effective Tax Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 154 - Disclosure - Income Taxes - Significant Components of the Company's Deferred Tax Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 155 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 156 - Disclosure - Income Taxes - Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits (Detail) link:calculationLink link:presentationLink link:definitionLink 157 - Disclosure - Net Loss Per Share - Computation of Net Loss Per Common Share (Detail) link:calculationLink link:presentationLink link:definitionLink 158 - Disclosure - Net Loss per Share - Calculation of Anti-dilutive Potentially Dilutive Securities Not Included in Diluted Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 159 - Disclosure - Related Party Transactions - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 160 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 161 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Payments Under the Noncancelable Operating Lease (Detail) link:calculationLink link:presentationLink link:definitionLink 162 - Disclosure - Selected Quarterly Financial Data (Unaudited) - Schedule of Selected Quarterly Financial Results from Operations (Detail) link:calculationLink link:presentationLink link:definitionLink