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Loan agreement covenant, net product revenue as percentage of outstanding loan balance, minimum Loan Agreement, Covenant, Net Product Revenue As Percentage Of Outstanding Loan Balance, Minimum Loan Agreement, Covenant, Net Product Revenue As Percentage Of Outstanding Loan Balance, Minimum Liabilities and stockholders’ equity Liabilities and Equity [Abstract] Non-cash interest expense Amortization of Debt Discount (Premium) Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Remaining funding based on milestone achievement Remaining Funding Based On Conditional Milestone Achievement Remaining Funding Based On Conditional Milestone Achievement Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Axis] Stockholders’ equity: Equity, Attributable to Parent [Abstract] Potential commercialization milestones Collaborative Arrangement, Potential Commercialization Milestones Collaborative Arrangement, Potential Commercialization Milestones Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Upfront payment Contract with Customer, Liability Issuance of common stock upon exercise of options (in shares) Options exercised (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Inventory Inventory Inventory, Gross Schedule of Computation of Net Loss Per Common Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Total cost of goods sold Cost of Goods and Services Sold Schedule of Noncurrent Inventory Schedule of Inventory, Noncurrent [Table Text Block] Executive Category: Executive Category [Axis] Number of RSUs Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Options exercised (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Level 1 Fair Value, Inputs, Level 1 [Member] Name Measure Name Name Forgone Recovery, Individual Name Loan agreement, covenant, cash and cash equivalents as percentage of outstanding loan balance, calculation period Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Calculation Period Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Calculation Period Purchases of investments Payments to Acquire Short-Term Investments Equity Components [Axis] Equity Components [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Accrued and other liabilities Increase (Decrease) in Accrued Liabilities Thereafter Lessee, Operating Lease, Liability, To Be Paid, After Year Three Lessee, Operating Lease, Liability, To Be Paid, After Year Three Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Options granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Underlying Securities Award Underlying Securities Amount Entity Small Business Entity Small Business Closing fee Debt Instrument, Closing Fee Amount Debt Instrument, Closing Fee Amount Local Phone Number Local Phone Number Total cash equivalents and investments, Gross Unrealized Losses Cash Cash Equivalents And Investments Gross Unrealized Losses Cash, cash equivalents and investments gross unrealized losses. 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Interest expense Interest Expense AmerisourceBergen Drug Corporation AmerisourceBergen Drug Corporation [Member] AmerisourceBergen Drug Corporation Potential development and commercialization milestones Collaborative Arrangement, Potential Development And Commercialization Milestones Represents the amount of future development and commercialization milestone under collaborative arrangements. 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Issuance of common stock in at the market offering (in shares) Stock Issued During Period, Shares, New Issues Options forfeited or canceled (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Title of 12(b) Security Title of 12(b) Security Short-term securities, contractual maturities maximum Available-For-Sale Securities, Debt Securities, Current, Contractual Maturities, Maximum Available-For-Sale Securities, Debt Securities, Current, Contractual Maturities, Maximum Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Short-term investments: Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract] Sublease income Sublease Income Threshold percentage of net sales for tiered royalties Threshold Percentage of Sales For Tiered Royalties Represents the threshold percentage of net sales for tiered royalties. 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Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-Sale [Table] Increases due to amounts reclassified from non-current, to be recognized in the next twelve months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Total Shareholder Return Amount Total Shareholder Return Amount Product sales, net Product [Member] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Knight Agreement License Agreement Development Commercialization Distribution In Canada [Member] Agreement for the development, commercialization and distribution fo tenapanor in Canada. The Knight Agreement. 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Current Fiscal Year End Date Current Fiscal Year End Date Fair value analysis, percentage change in probability of occurrence Fair Value Sensitivity Analysis, Change In Probability Of Occurrence, Percentage Fair Value Sensitivity Analysis, Change In Probability Of Occurrence, Percentage Total of shares sold (in shares) Equity Sales Agreement, Shares Issued Since Inception Equity Sales Agreement, Shares Issued Since Inception Proceeds from milestone payments Revenue, Remaining Performance Obligation, Variable Consideration Amount Revenue, Remaining Performance Obligation, Variable Consideration Amount Number of payment tranches for fee receivable for reduction in royalty rate Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate, Number Of Payment Tranches Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate, Number Of Payment Tranches PEO Name PEO Name Concentration risk (percent) Concentration Risk, Percentage Estimated fair value Beginning balance Ending balance Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Asset backed securities Asset-backed securities Asset-Backed Securities [Member] Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Class of Stock [Axis] Class of Stock [Axis] 2018 Term Loan Term Loan 2018 [Member] Term Loan 2018 Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] Short-term investments Debt Securities, Available-for-Sale, Current Less: Unaccreted value of final fee Debt Instrument, Fee Amount After second anniversary to maturity date Debt Instrument, Redemption, Period Three [Member] Fosun Agreement License Agreement Development Commercialization Distribution In China [Member] Agreement for the development, commercialization and distribution of tenapanor in China. The Fosun Agreement. 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