Document And Entity Information [Abstract] Document And Entity Information [Abstract] Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Document Type Document Type Document Period End Date Document Period End Date Current Fiscal Year End Date Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Entity Current Reporting Status Entity Current Reporting Status Entity Interactive Data Current Amendment Flag Amendment Flag Entity Filer Category Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Ex Transition Period Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Condensed Balance Sheets Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and cash equivalents Cash and cash equivalents, Amortized Cost Available-for-sale Securities, Debt Securities, Current Short-term investments Accounts Receivable, Net Accounts receivable Contract with Customer, Asset, Net, Current Unbilled license revenue Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Current assets Total current assets Property, Plant and Equipment, Net Property and equipment, net Operating Lease, Right-of-Use Asset Right-of-use assets Right-of-use assets Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation and benefits Contract with Customer, Liability, Current Uncharged license fees Operating Lease, Liability, Current Current portion of lease liabilities Current portion of operating lease liability Accrued Liabilities and Other Liabilities Accrued and other liabilities Accrued liabilities and other liabilities Liabilities, Current Current liabilities Total current liabilities Operating Lease, Liability, Noncurrent Operating lease liability, net of current portion Operating lease liability, net of current portion Loans Payable, Noncurrent Loan payable, long term Loan payable, long term Liabilities, Other than Long-term Debt, Noncurrent Other long-term liabilities Liabilities Total liabilities Commitments and Contingencies Commitments and contingencies Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.0001 par value; 5,000,000 shares authorized; no shares issued and outstanding as of September 30, 2019 and December 31, 2018, respectively Common Stock, Value, Issued Common stock, $0.0001 par value; 300,000,000 shares authorized; 62,883,080 and 62,516,627 shares issued and outstanding as of September 30, 2019 and December 31, 2018, respectively. Additional Paid in Capital, Common Stock Additional paid-in capital Retained Earnings (Accumulated Deficit) Accumulated deficit Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income (loss) Stockholders' Equity Attributable to Parent Balance, amount Balance, amount Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common stock issued Common Stock, Shares, Outstanding Common stock, shares outstanding Condensed Consolidated Statements of Operations and Comprehensive Loss Statement [Table] Products and Services [Axis] Products And Services [Domain] Products and Services [Domain] Represents the information pertaining to revenues from other product or services. Other Product Or Services Revenue [Member] Other Statement [Line Items] Revenues [Abstract] Revenues: Revenues Total revenues Revenue from Contract with Customer, Excluding Assessed Tax Total revenue Cost of Revenue Cost of revenue Gross Profit Gross profit Operating Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Operating Expenses Total operating expenses Operating Income (Loss) Loss from operations Interest Expense Interest expense Other Nonoperating Income (Expense) Other income (expense), net Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Loss before provision for income taxes Income Tax Expense (Benefit) Provision for income taxes Net Income (Loss) Attributable to Parent Net loss Net loss Earnings Per Share, Basic and Diluted Net loss per share - basic and diluted Net loss per common share, basic and diluted Weighted Average Number of Shares Outstanding, Basic and Diluted Weighted average common shares outstanding - basic and diluted Shares used in computing net loss per share - basic and diluted Comprehensive loss: Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Other comprehensive loss Unrealized (loss) gain on available-for-sale securities, net of tax Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Condensed Statements of Changes in Stockholders' Equity Shares, Outstanding Balance, shares Balance, shares Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock under employee stock purchase plan, amount Proceeds Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock under employee stock purchase plan, shares Number of shares issued under ESPP Stock Issued During Period, Value, Issued for Services Issuance of common stock for services, amount Stock Issued During Period, Shares, Issued for Services Issuance of common stock for services, shares Issuance of common stock for services, shares Stock Issued During Period, Value, Stock Options Exercised Issuance of common stock upon exercise of options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Issuance of common stock upon exercise of options, shares Number of options exercised Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation Stock Issued During Period, Value, New Issues Issuance of common stock, value Stock Issued During Period, Shares, New Issues Issuance of common stock, shares Cumulative Effect of New Accounting Principle in Period of Adoption Adoption of ASU No. 2014-09 on January 1, 2018 Condensed Consolidated Statements of Cash Flows Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation Depreciation expense Amortization of Debt Issuance Costs Amortization of deferred financing costs Amortization of Deferred Charges Amortization of deferred compensation for services Accretion (Amortization) of Discounts and Premiums, Investments Amortization of premium on investment securities The amount of non cash lease expense. Non Cash Lease Expense Non-cash lease expense Share-based Compensation Stock-based compensation Increase (Decrease) in Derivative Liabilities Change in derivative liabilities Settlement of forward foreign currency exchange contract in the aggregate notional amount of Swiss francs Non-cash interest expense. Noncash Interest Expense Non-cash interest associated with debt discount accretion Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Receivables Accounts receivable and unbilled license revenue Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Employee Related Liabilities Accrued compensation and benefits Represents element information pertaining to increase decrease in operating lease liabilities. Increase Decrease in Operating Lease Liabilities Lease liabilities Increase (Decrease) in Accrued Liabilities Accrued and other liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Investing activities Proceeds from Maturities, Prepayments and Calls of Short-term Investments Proceeds from maturities of investments Proceeds from Sale of Other Investments Sales and redemptions of investments Payments to Acquire Short-term Investments Purchases of investments Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Financing activities Proceeds from Debt, Net of Issuance Costs Proceeds from loan payable, net of issuance costs Net proceeds from the loan Sale of Stock, Consideration Received on Transaction Proceeds from underwritten public offering, net of issuance costs Proceeds from Stock Options Exercised Net proceeds from stock option exercised Issuance of common stock upon exercise of options Amount of cash inflow from issuance of shares under share-based payment arrangement. Includes, but is not limited to, option exercised. Proceeds from issuance of common stock under stock plans Proceeds from issuance of common stock under stock plans Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Cash and Cash Equivalents, Period Increase (Decrease) Net increase (decrease) in cash and cash equivalents Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Supplementary disclosure of non-cash financing information: Represents the non-cash issuance of derivative in connection with issuance of loan payable. Issuance Of Derivative In Connection With Issuance Of Loan Payable Issuance of derivative in connection with issuance of loan payable Organization and Basis of Presentation Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Organization and Basis of Presentation Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Cash, Cash Equivalents and Investments Cash, Cash Equivalents, and Short-term Investments [Text Block] Cash, Cash Equivalents and Investments Fair Value Measurements Fair Value Disclosures [Text Block] Fair Value Measurements Derivative Financial Instruments Derivative Instruments And Hedging Activities Disclosure [Text Block] Derivative Financial Instruments Borrowings Debt Disclosure [Text Block] Borrowings Leases Lessee, Operating Leases [Text Block] Leases Shareholders Equity Stockholders' Equity Note Disclosure [Text Block] Shareholders Equity Stock-Based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-Based Compensation Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share Accrued and Other Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accrued and Other Liabilities n/a Collaboration and Licensing Agreements Collaborative Arrangement Disclosure [Text Block] Collaboration and Licensing Agreements Contingencies. Commitments and Contingencies Disclosure [Text Block] Contingencies Use of Estimates, Policy [Policy Text Block] Use of Estimates Accrued research and development expenses policy. Accrued Research and Development Expenses Policy [Policy Text Block] Accrued Research and Development Expenses Revenue Recognition, Policy [Policy Text Block] Revenue Recognition Derivatives, Reporting of Derivative Activity [Policy Text Block] Derivatives and Hedging Activities Lessee, Leases [Policy Text Block] Leases New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Fair Value Measurement, Policy [Policy Text Block] Fair Value Measurements New Accounting Pronouncements or Change in Accounting Principle [Table] New Accounting Pronouncements or Change in Accounting Principle [Line Items] Summary of significant accounting policies Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block] Schedule of adjustments of topic 842 Cash, Cash Equivalents and Investments [Table Text Block] Schedule of Securities Classified as Cash, Cash Equivalents and Short-Term Investments Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Summary of Fair Value Measurements of Company's Financial Assets and Liabilities Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Summary of Changes in the Fair Value of Recurring Measurements Schedule of Maturities of Long-term Debt [Table Text Block] Schedule of Future Debt Payment Obligations The tabular disclosure of additional details of the leases. Schedule of Additional Details of Leases [Table Text Block] Summary of Additional Details of the Leases Lease, Cost [Table Text Block] Summary of Lease Costs Lessee, Operating Lease, Liability, Maturity [Table Text Block] Summary of Undiscounted Cash Payment Obligations for its Operating Lease Liabilities Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Summary of Stock-Based Compensation Expense Recognized Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block] Summary of Total Unrecognized Stock-Based Compensation Expense, Net of Estimated Forfeitures Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Computation of Basic and Diluted Loss Per Share Attributable to Common Stockholders Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] Schedule of Accrued Liabilities and Other Liabilities The tabular disclosure of cost of revenue recognized and amount of cost paid. Cost of Revenue [Table Text Block] Schedule of Cost of Revenue Recognized and Paid Number of Operating Segments Number of operating segments Schedule of Error Corrections and Prior Period Adjustment Restatement [Table] Error Corrections and Prior Period Adjustments Restatement [Line Items] Schedule of Quantifying Prior Year Misstatement Corrected in Current Year Financial Statements [Table] Quantifying Misstatement in Current Year Financial Statements [Line Items] Quantifying Misstatement in Current Year Financial Statements, Amount Correction of cumulative errors Adjustments for New Accounting Pronouncements [Axis] Type Of Adoption [Member] Type of Adoption [Domain] Accounting Standards Update201409 [Member] ASU 2014-09 Initial Application Period Cumulative Effect Transition [Axis] Initial Application Period Cumulative Effect Transition [Domain] Initial Application Period Cumulative Effect Transition [Domain] Difference Between Revenue Guidance In Effect Before And After Topic606 [Member] Adjustments Liabilities, Noncurrent Other long-term liabilities Operating Lease, Expense Lease expense Cash and cash equivalents and short term investments. Cash Cash Equivalents And Short Term Investments [Table] Financial Instrument [Axis] Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Major Types of Debt and Equity Securities [Domain] U S Treasury Securities [Member] U.S. Treasury Securities [Member] Corporate Debt Securities [Member] Corporate Bonds (Investments) [Member] Commercial Paper Not Included With Cash And Cash Equivalents [Member] Commercial Paper (Investments) [Member] Asset Backed Securities [Member] Asset-Backed Securities [Member] Cash and Cash Equivalents [Axis] Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member] Cash and Cash Equivalents [Domain] Cash [Member] Cash [Member] Money Market Funds [Member] Money Market Funds [Member] Commercial Paper [Member] Commercial Paper (Cash Equivalents) [Member] Cash and cash equivalents and short term investments. Cash Cash Equivalents And Short Term Investments [Line Items] Cash and Cash Equivalents, Fair Value Disclosure Cash and cash equivalents, Fair Value Available-for-sale Securities, Amortized Cost Basis Short-term investments, Amortized Cost Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Short-term investments, Gross Unrealized Gains Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax Short-term investments, Gross Unrealized Losses Available-for-sale Securities Short-term investments, Fair Value Cash, Cash Equivalents, and Short-term Investments Cash equivalents and short-term investments, Amortized Cost Cash, cash equivalents and short term investments gross unrealized gains. Cash Cash Equivalents And Short Term Investments Gross Unrealized Gains Cash equivalents and short-term investments, Gross Unrealized Gains Cash, cash equivalents and short term investments gross unrealized losses. Cash Cash Equivalents And Short Term Investments Gross Unrealized Losses Cash equivalents and short-term investments, Gross Unrealized Losses Cash, cash equivalents and short term investments fair value disclosure. Cash Cash Equivalents And Short Term Investments Fair Value Disclosure Cash equivalents and short-term investments, Fair Value Range [Axis] Range [Member] Range [Domain] Maximum [Member] Maximum [Member] Available for sale securities contractual maturity period. Available For Sale Securities Contractual Maturity Period Available for sale securities contractual maturity period Available-for-sale Securities, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Investment in continuous unrealized loss position for more than one year Fair Value Measurements, Recurring and Nonrecurring [Table] Asset Class [Axis] Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Asset Class [Domain] Domestic Corporate Debt Securities Including Cash Equivalents [Member] Domestic Corporate Debt Securities Including Cash Equivalents [Member] Corporate Bonds [Member] Commercial Paper Cash Equivalents Including Securities [Member] Commercial Paper Cash Equivalents Including Securities [Member] Commercial Paper [Member] Liability Class [Axis] Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation By Liability Class [Domain] Fair Value by Liability Class [Domain] This represents information pertaining to derivative liability exit fees. Derivative Liability Exit Fee [Member] Derivative Liability Exit Fee [Member] Foreign Exchange Contract [Member] Foreign Currency Derivative Contracts [Member] Measurement Frequency [Axis] Fair Value Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value Measurements Recurring [Member] Fair Value, Recurring [Member] Fair Value, Hierarchy [Axis] Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value Inputs Level1 [Member] Level 1 [Member] Fair Value Inputs Level2 [Member] Level 2 [Member] Fair Value Inputs Level3 [Member] Level 3 [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value Measurements Assets, Fair Value Disclosure [Abstract] Assets: Assets, Fair Value Disclosure Assets at fair value Liabilities: Financial and Nonfinancial Liabilities, Fair Value Disclosure Derivative liability Estimated fair value of Exit Fee Fair Value, Assets, Level 1 to Level 2 Transfers, Amount Transfer of assets from Level 1 to Level 2 Fair Value, Assets, Level 2 to Level 1 Transfers, Amount Transfer of assets from Level 2 to Level 1 Debt Instrument [Axis] Debt Instrument Name [Domain] Debt Instrument, Name [Domain] Represents the information pertaining to Solar Capital and Western Alliance Bank Loan Agreement. Solar Capital And Western Alliance Bank Loan Agreement [Member] Solar Capital and Western Alliance Bank Loan Agreement [Member] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Represents information pertaining to accrued and other liabilities. Accrued And Other Liabilities [Member] Accrued and other liabilities Business Exit Costs Exit Fee Amount of increase in estimated fair value of exit fee. Increase in Estimated Fair Value of Exit Fee Increase in estimated fair value of Exit Fee Amount of potential milestone payment as a result of FDA approval. Fair Value Inputs, Potential Milestone Payment as Result of Food and Drugs Administration Approval Potential payment to Solar Capital Ltd. and Western Alliance Bank The reasonably possible percentage of the increase in the designated risk component used to determine the value of the financial instrument. Excludes defined benefit plan obligations. Percentage of Reasonably Possible Increase in Risk Assumption Percentage of increase in risk component The reasonably possible percentage of the decrease in the designated risk component used to determine the value of the financial instrument. Excludes defined benefit plan obligations. Percentage of Reasonably Possible Decrease in Risk Assumption Percentage decrease in risk component The increase (decrease) in a financial instrument as a result of an increase in a designated risk component that was reasonably possible at the end of the reporting period. Excludes defined benefit plan obligations. Increase (Decrease) in Financial Instrument Due to Reasonably Possible Increase in Designated Risk Component Fair value fluctuation due to increase in risk component The increase (decrease) in a financial instrument as a result of an decrease in a designated risk component that was reasonably possible at the end of the reporting period. Excludes defined benefit plan obligations. Increase (Decrease) in Financial Instrument Due to Reasonably Possible Decrease in Designated Risk Component Fair value fluctuation due to decrease in risk component Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Value Ending Balance Beginning Balance Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Gain (Loss) Included in Earnings Change in estimated fair value of derivative liability for exit fee Derivative [Table] Derivative Instrument [Axis] Derivative Contract Type [Domain] Derivative Contract [Domain] Derivative [Line Items] Derivative Instruments Not Designated as Hedging Instruments, Gain (Loss), Net Gain (loss) on derivative instruments Schedule of Long-term Debt Instruments [Table] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] London Interbank Offered Rate L I B O R [Member] LIBOR Debt Instrument, Redemption, Period [Axis] Debt Instrument Redemption Period [Domain] Debt Instrument, Redemption, Period [Domain] This member represents redemption of debt at maturity date under the terms of the debt agreement. At Maturity [Member] At Maturity Debt Instrument Redemption Period One [Member] Prior to first anniversary of closing date Debt Instrument Redemption Period Two [Member] After first anniversary of closing date This member represents period of redemption of debt after second anniversary to maturity date under the terms of the debt agreement. After Second Anniversary To Maturity Date [Member] After second anniversary to maturity date Debt Instrument [Line Items] Term Loans Long-term Debt, Gross Amount of term loan facility Debt Instrument, Basis Spread on Variable Rate Floating interest rate The percentage of premium payable on principal amount of the term loan at or before maturity redemption. Percentage of Premium Payable on Redemption of the Term Loan Percentage of premium payable on redemption of the term loan The amount of fee payable upon closing of the term loan. Fee Payable upon Closing of the Term Loan Amount of fee payable upon closing of the term loan The percentage of fee payable on prepayment of debt. Prepayment Fee Percentage Prepayment fee (as a percent) Percentage fee of original principal amount of debt at which debt can be redeemed by the issuer. Debt Instrument Final Payment Fee Percentage Final payment fee (as a percent) The percentage on the term loan payable as exit fee under the terms of debt agreement. Percentage of Exit Fee Exit fee (as a percent) The expiration term of exit fee, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Exit Fee Expiration Term Expiration term of exit fee Minimum unrestricted cash and cash equivalents to be maintained under the terms of debt agreement. Minimum Unrestricted Cash and Cash Equivalents to be Maintained Minimum unrestricted cash and cash equivalents to be maintained Percentage of additional default interest rate on the event of default. Default Interest Rate Additional default interest rate Long-term Debt, Fiscal Year Maturity [Abstract] Future debt payment obligations Long-term Debt, Maturities, Repayments of Principal in Year Two 2020 Long-term Debt, Maturities, Repayments of Principal in Year Three 2021 Long-term Debt, Maturities, Repayments of Principal in Year Four 2022 Long-term Debt Total Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Less: Unamortized discount and debt issuance costs The unaccreted value of final fee of debt instrument. Debt Instrument, Unaccreted Value, Final Fee Less: Unaccreted value of final fee Lessee, Lease, Description [Table] Lessee, Lease, Description [Line Items] Represents the number of operating lease arrangements. Number of Operating Lease Arrangements Number of operating lease arrangements Area of Real Estate Property Area of office space Lessee, Operating Lease, Existence of Option to Extend [true/false] Option to extend Lessee, Operating Lease, Renewal Term Renewal term Represents the threshold period for giving notice of lease extension. Threshold Period for Giving Notice of Lease Extension Threshold period for giving notice of lease extension Operating Lease, Weighted Average Discount Rate, Percent Weighted-average discount rate Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining life Assets and Liabilities, Lessee [Abstract] Additional details of the leases Operating Lease, Liability Total liabilities Total lease liabilities Lease, Cost [Abstract] Facilities Operating Lease, Cost Operating lease cost Operating Lease, Payments Cash paid for operating lease Operating Lease Liabilities, Payments Due [Abstract] Undiscounted cash payment obligations for its operating lease liabilities Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year 2019 (remaining three months) Lessee, Operating Lease, Liability, Payments, Due Year Two 2020 Lessee, Operating Lease, Liability, Payments, Due Year Three 2021 Lessee, Operating Lease, Liability, Payments, Due Total lease payments Lessee, Operating Lease, Liability, Undiscounted Excess Amount Imputed interest Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Sale of Stock [Axis] Sale Of Stock Name Of Transaction [Domain] Sale of Stock [Domain] Represents information pertaining to common stock issuance May 2018 offering. Common Stock Issuance May2018 Offering [Member] Offering Over Allotment Option [Member] Underwriters' option Subsidiary, Sale of Stock [Line Items] Share Price Purchase price Public offering price Represents the per share amount of underwriting discounts and commissions. Underwriting discounts and commissions per share Underwriting discounts and commissions per share Purchase price of single share of a company. Share Purchase Price Purchase price Proceeds from Issuance of Common Stock Net proceeds Share-based Compensation Arrangement by Share-based Payment Award, Options Outstanding, Weighted Average Exercise Price, and Additional Disclosures [Abstract] Share-based Compensation Arrangement by Share-based Payment Award, Options Outstanding, Weighted Average Exercise Price, and Additional Disclosures [Abstract] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research And Development Expense [Member] Research and development General And Administrative Expense [Member] General and administrative Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Allocated Share-based Compensation Expense Stock based compensation expenses Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized Compensation Expense Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Average Vesting Period Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Award Type [Axis] Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Equity Award [Domain] Employee Stock Option [Member] Options to Purchase Common Stock [Member] Restricted Stock Units R S U [Member] Restricted Stock Units (RSUs) [Member] This member stands for performance-based restricted stock units. Performance Based Restricted Stock Units [Member] Performance-Based Restricted Stock Units (PRSUs) [Member] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Number of shares, Granted Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Number of Shares, Outstanding Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Number of shares issued upon vesting of restricted stock units Net Income (Loss) Attributable to Parent [Abstract] Numerator: Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Denominator: Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Anti-dilutive securities excluded from computation of diluted net loss per share attributable to common stockholders Accrued clinical and nonclinical expenses. Accrued Clinical And Nonclinical Expenses Accrued clinical and non-clinical expenses Accrued contract manufacturing costs. Accrued Contract Manufacturing Costs Accrued contract manufacturing expenses Amount of derivative liability for exit fee. Derivative Liability for Exit Fee Derivative liability for exit fee Accrued professional and consultant fees current. Accrued Professional And Consultant Fees Current Accrued professional and consulting services Amount of foreign currency derivative contract expenses. Foreign Currency Derivative Contract Expenses Foreign currency derivative contract Other Liabilities, Current Other Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Counterparty Name [Axis] Repurchase Agreement Counterparty Name [Domain] Counterparty Name [Domain] This member stands for Kyowa Hakko Kirin. Kyowa Hakko Kirin [Member] Kyowa Hakko Kirin [Member] This member stands for Shanghai Fosun Pharmaceutical Industrial Development. Shanghai Fosun Pharmaceutical Industrial Development [Member] Shanghai Fosun Pharmaceutical Industrial Development [Member] Astra Zeneca [Member] Astra Zeneca [Member] AstraZeneca [Member] Represents information pertaining to Knight Therapeutics Inc. Knight Therapeutics Inc [Member] Knight Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements And Nonarrangement Transactions [Member] Arrangements and Non-arrangement Transactions [Domain] Represents information pertaining to development and commercialization milestone. Development And Commercialization [Member] Development and Commercialization [Member] Represents information pertaining to termination agreement. Termination Agreement [Member] Termination Agreement [Member] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Proceeds from License Fees Received Upfront payment received Increase (Decrease) in Contract with Customer, Liability Uncharged license fees reclassed to accounts payable Contract with Customer, Liability Payment of uncharged license fee The amount of development milestones payment to be received under collaborative arrangements. Collaborative Arrangement Development Milestones Payment To Be Received Development milestones The amount of development milestone payment received to date. Collaborative Arrangement Development Milestones Payment Received Development milestones Received The amount of commercialization milestones payment to be received under collaborative arrangements. Collaborative Arrangement Commercialization Milestones Payment To Be Received Commercialization milestones Represents the amount of future development and commercialization milestone under collaborative arrangements. Collaborative Arrangement Future Development And Commercialization Milestones Future development milestones Represents the threshold percentage of net sales for tiered royalties. Threshold Percentage of Sales For Tiered Royalties Threshold percentage of net sales for tiered royalties The amount of upfront payments and development and sales milestones payment to be received under collaborative arrangements. Collaborative Arrangement Up Front Payment And Development And Sales Milestones Payment To Be Received Total payments, including an up-front payment and development and sales milestones to be received Represents percentage of royalty revenue. Percentage of Royalty Revenue Percentage of royalty revenue (as a percent) Represents percentage of non-royalty revenue. Percentage of non royalty revenue Percentage of non royalty revenue (as a percent) Represents the cash outflow from payments of uncharged license fees. Payments of Uncharged License Fees Cost of revenue, Amount Paid The amount of withholding tax for milestone payment received. Withholding Tax, Milestone Payment Withholding tax Accounts Payable and Accrued Liabilities, Noncurrent Remaining balance License [Member] Licensing Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock [Member] Additional Paid In Capital [Member] Additional Paid-In Capital [Member] Retained Earnings [Member] Accumulated Deficit [Member] Accumulated Other Comprehensive Income [Member] Other Comprehensive Income (Loss) [Member] Accounting Standards Update201602 [Member] ASU 2016-02 Adjustments for Error Corrections [Axis] Adjustments For Error Correction [Domain] Adjustments for Error Correction [Domain] Represent the information relating to the Overstatement due to clinical trial accruals errors Overstatement Due To Clinical Trial Accruals Errors [Member] Overstatement due to clinical trial accrual errors Restatement [Axis] Restatement [Domain] Restatement [Domain] Restatement Adjustment [Member] Effect of Change Nature of Error [Axis] Nature Of Error [Domain] Nature of Error [Domain] Represent the information relating to the reduction in accrued and other liabilities. Reduction In Accrued And Other Liabilities [Member] Reduction in accrued and other liabilities Represent the information relating to the reduction in research and development expenses . Reduction In Research And Development Expenses [Member] Reduction in research and development expenses Scenario Previously Reported [Member] Under Topic 840 Other Operating Income Expense [Member] Other income (expense), net Minimum [Member] Minimum [Member]