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Disclosure - Cash, Cash Equivalents and Short-Term Investments link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Product Revenue, Net link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Collaboration and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Deferred Royalty Obligation Related To The Sale Of Future Royalties link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Borrowings link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Derivative Liabilities link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 0000019 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 0000020 - Disclosure - Equity Incentive Plans link:presentationLink link:calculationLink link:definitionLink 0000021 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 0000022 - Disclosure - Property and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 0000023 - Disclosure - Accrued Expenses and Other Current Liabilities link:presentationLink link:calculationLink link:definitionLink 0000024 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0000025 - Disclosure - Geographic Information and Concentrations link:presentationLink link:calculationLink link:definitionLink 0000026 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 0000027 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 0000028 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 0000029 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 0000030 - Disclosure - Cash, Cash Equivalents and Short-Term Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 0000031 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 0000032 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 0000033 - Disclosure - Product Revenue, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 0000034 - Disclosure - Collaboration and Licensing Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 0000035 - Disclosure - Borrowings (Tables) link:presentationLink link:calculationLink link:definitionLink 0000036 - Disclosure - Derivative Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 0000037 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 0000038 - Disclosure - Equity Incentive Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 0000039 - Disclosure - Property and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 0000040 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 0000041 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 0000042 - Disclosure - Geographic Information and Concentrations (Tables) link:presentationLink link:calculationLink link:definitionLink 0000043 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 0000044 - Disclosure - Organization and Basis of Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 0000045 - Disclosure - Summary of Significant Accounting Policies - Liquidity (Details) link:presentationLink link:calculationLink link:definitionLink 0000046 - Disclosure - Summary of Significant Accounting Policies - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 0000047 - Disclosure - Summary of Significant Accounting Policies - Product Sales Net (Details) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Securities Classified as Cash and Short-Term Investments (Details) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Fair Value Measurements - Financial Assets and Liabilities Measured on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Fair Value Measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000053 - Disclosure - Inventory - Schedule (Details) link:presentationLink link:calculationLink link:definitionLink 0000054 - Disclosure - Inventory - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000055 - Disclosure - Product Revenue, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000056 - Disclosure - Product Revenue, Net - Gross-to-Net Sales Accruals (Details) link:presentationLink link:calculationLink link:definitionLink 0000057 - Disclosure - Collaboration and Licensing Agreements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000058 - Disclosure - Collaboration and Licensing Agreements - Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Deferred Royalty Obligation Related To The Sale Of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Borrowings - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Borrowings - Future Payment Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Borrowings - Future Payment Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Derivative Liabilities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Derivative Liabilities - Changes in Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000065 - Disclosure - Leases - Additional Lease Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000066 - Disclosure - Leases - Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 0000067 - Disclosure - Leases - Undiscounted Cash Payment Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 0000067 - Disclosure - Leases - Undiscounted Cash Payment Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 0000068 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 0000069 - Disclosure - Equity Incentive Plans - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000070 - Disclosure - Equity Incentive Plans - Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 0000071 - Disclosure - Equity Incentive Plans - Valuation Assumptions for Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 0000072 - Disclosure - Equity Incentive Plans - Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 0000073 - Disclosure - Equity Incentive Plans - Employee Stock Purchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 0000074 - Disclosure - Equity Incentive Plans - Valuation Assumptions for ESPP (Details) link:presentationLink link:calculationLink link:definitionLink 0000075 - Disclosure - Equity Incentive Plans - Stock-Based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 0000076 - Disclosure - Equity Incentive Plans - Unrecognized Stock-Based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 0000077 - Disclosure - Restructuring (Details) link:presentationLink link:calculationLink link:definitionLink 0000078 - Disclosure - Property and Equipment, Net - Balances (Details) link:presentationLink link:calculationLink link:definitionLink 0000079 - Disclosure - Property and Equipment, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000080 - Disclosure - Accrued Expenses and Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000081 - Disclosure - Income Taxes - Components of Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 0000082 - Disclosure - Income Taxes - Reconciliation of Effective Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 0000083 - Disclosure - Income Taxes - Components of Deferred Tax Assets (Details) link:presentationLink link:calculationLink link:definitionLink 0000084 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000085 - Disclosure - Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 0000086 - Disclosure - Geographic Information and Concentrations - Revenue by Geographical Area (Details) link:presentationLink link:calculationLink link:definitionLink 0000087 - Disclosure - Geographic Information and Concentrations - Concentration Risk (Details) link:presentationLink link:calculationLink link:definitionLink 0000088 - Disclosure - Net Loss Per Share - Computation of Net Loss Per Common Share (Details) link:presentationLink link:calculationLink link:definitionLink 0000089 - Disclosure - Net Loss Per Share - Anti-Dilutive Securities and Potential Common Shares (Details) link:presentationLink link:calculationLink link:definitionLink 0000090 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 0000091 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink