Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Changes in estimated fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings Variable Rate [Domain] Variable Rate [Domain] Pay vs Performance Disclosure [Line Items] Statistical Measurement [Domain] Statistical Measurement [Domain] Agreed amount for exit fee upon occurrence of certain conditions Agreed amount for exit fee upon change of control or regulatory approval Derivative Liability, Notional Amount Research and development Research and Development Expense Amounts invoiced as prepayments for product supply Contract With Customer, Liability, Revenue Invoiced As Prepayments For Product Supply, Current Contract With Customer, Liability, Revenue Invoiced As Prepayments For Product Supply, Current Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Underlying Security Market Price Change Underlying Security Market Price Change, Percent Additional default interest rate (as percent) Debt Instrument, Interest Rate On Default, Percentage Percentage of additional default interest rate on the event of default. Award Type [Domain] Award Type [Domain] Fair Value as of Grant Date Award Grant Date Fair Value Outstanding balance, beginning (in shares) Outstanding balance, ending (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Borrowing Debt Disclosure [Text Block] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Schedule of Additional Details of Leases Schedule Of Additional Details Of Leases [Table Text Block] The tabular disclosure of additional details of the leases. Schedule of Securities Classified as Cash, Cash Equivalents and Investments Cash, Cash Equivalents and Investments [Table Text Block] MNPI Disclosure Timed for Compensation Value MNPI Disclosure Timed for Compensation Value [Flag] Accounts payable Accounts Payable, Current Restatement Determination Date: Restatement Determination Date [Axis] Corporate bonds Corporate bonds Corporate Debt Securities [Member] Other income, net Nonoperating Income (Expense) Commitments and contingencies (Note 14) Commitments and Contingencies Undiscounted cash payment obligations Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] Insider Trading Policies and Procedures [Line Items] Options exercisable (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Stockholders' Equity Equity [Text Block] Proceeds from issuance of common stock in at the market offering, net of issuance costs Proceeds from Issuance of Common Stock Geographical [Axis] Geographical [Axis] Current portion of long-term debt Less: Current portion of long-term debt Loans Payable, Current Proceeds from ESPP Proceeds from Stock Plans Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Issuance of common stock upon vesting of restricted stock units (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Board of directors Director [Member] Customer [Axis] Customer [Axis] Current liabilities: Liabilities, Current [Abstract] Waltham, Massachusetts Waltham, Massachusetts [Member] Waltham, Massachusetts Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, $0.0001 par value; 5,000,000 shares authorized; no shares issued and outstanding as of September 30, 2023 and December 31, 2022, respectively. Preferred Stock, Value, Issued Weighted-Average Grant Date Fair Value Per Share Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Net income (loss) per common stock - diluted (in dollars per share) Net income (loss) per share of common stock - diluted (in dollars per share) Earnings Per Share, Diluted PEO Total Compensation Amount PEO Total Compensation Amount Accounts receivable Accounts Receivable, after Allowance for Credit Loss, Current Trading Arrangements, by Individual Trading Arrangements, by Individual [Table] Level 3 Fair Value, Inputs, Level 3 [Member] Options outstanding balance, beginning (in shares) Options outstanding balance, ending (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Litigation Case [Axis] Litigation Case [Axis] Issuance of common stock upon exercise of options Stock Issued During Period, Value, Stock Options Exercised Trading Symbol Trading Symbol Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount Options granted (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Beginning balance Ending balance Contract With Customer, Gross To Net Sales Accruals Contract With Customer, Gross To Net Sales Accruals Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Net income (loss) Net income (loss) Net Income (Loss) Attributable to Parent Net Income (Loss) Total current liabilities Liabilities, Current Fee receivable for reduction in royalty rate Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate Derivative Contract [Domain] Derivative Contract [Domain] Advance Royalties [Abstract] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Company Selected Measure Name Company Selected Measure Name Copay and Returns Contract With Customer, Other Fees, Copay And Returns [Member] Contract With Customer, Other Fees, Copay And Returns Leases Lessee, Operating Leases [Text Block] KKC Kyowa Kirin Co. Ltd [Member] Represents the information pertaining to Kyowa Kirin Co., Ltd. Loan agreement covenant, net product revenue as percentage of outstanding loan balance, minimum Loan Agreement, Covenant, Net Product Revenue As Percentage Of Outstanding Loan Balance, Minimum Loan Agreement, Covenant, Net Product Revenue As Percentage Of Outstanding Loan Balance, Minimum Liabilities and stockholders’ equity Liabilities and Equity [Abstract] Non-cash interest expense Amortization of Debt Discount (Premium) Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Remaining funding based on milestone achievement Remaining Funding Based On Conditional Milestone Achievement Remaining Funding Based On Conditional Milestone Achievement Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Axis] Stockholders’ equity: Equity, Attributable to Parent [Abstract] Potential commercialization milestones Collaborative Arrangement, Potential Commercialization Milestones Collaborative Arrangement, Potential Commercialization Milestones Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Revenue to be received Contract with Customer, Liability Issuance of common stock upon exercise of options (in shares) Options exercised (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Inventory Inventory Inventory, Gross Schedule of Computation of Net Loss Per Common Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Total cost of goods sold Cost of Goods and Services Sold Schedule of Noncurrent Inventory Schedule of Inventory, Noncurrent [Table Text Block] Executive Category: Executive Category [Axis] Number of RSUs Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Options exercised (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Level 1 Fair Value, Inputs, Level 1 [Member] Name Measure Name Name Forgone Recovery, Individual Name Loan agreement, covenant, cash and cash equivalents as percentage of outstanding loan balance, calculation period (in months) Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Calculation Period Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Calculation Period Purchases of investments Payments to Acquire Short-Term Investments Equity Components [Axis] Equity Components [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Accrued and other liabilities Increase (Decrease) in Accrued Liabilities Thereafter Lessee, Operating Lease, Liability, To Be Paid, After Year Three Lessee, Operating Lease, Liability, To Be Paid, After Year Three Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Options granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Underlying Securities Award Underlying Securities Amount Entity Small Business Entity Small Business Closing fee Debt Instrument, Closing Fee Amount Debt Instrument, Closing Fee Amount Local Phone Number Local Phone Number Total cash equivalents and investments, Gross Unrealized Losses Cash Cash Equivalents And Investments Gross Unrealized Losses Cash, cash equivalents and investments gross unrealized losses. Accounts receivable Increase (Decrease) in Accounts Receivable Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Selling, general and administrative Selling, General and Administrative Expenses [Member] Percentage of royalty revenue Percentage of Royalty Revenue Represents percentage of royalty revenue. Measurement Frequency [Axis] Measurement Frequency [Axis] Operating lease liability, net of current portion Operating lease liability, net of current portion Operating Lease, Liability, Noncurrent Royalty payments and commercial milestone payments Increase (Decrease) in Royalties Payable RSU grants Restricted stock units Restricted Stock Units (RSUs) [Member] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Cardinal Health Cardinal Health [Member] Cardinal Health Income Statement Location [Axis] Income Statement Location [Axis] Arrangements and Non-arrangement Transactions [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Decrease for revenue recognized for product supply Contract With Customer, Liability, Revenue Recognized Cash Not Received, Current Contract With Customer, Liability, Revenue Recognized Cash Not Received, Current Less: Unamortized discount and debt issuance costs Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net U.S. government-sponsored agency bonds U.S. government-sponsored agency bonds US Government Corporations and Agencies Securities [Member] Schedule of Undiscounted Cash Payment Obligations for Operating Lease Liabilities Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block] Fair Value by Liability Class [Domain] Fair Value by Liability Class [Domain] Transaction costs Contract With Customer, Liability, Transaction Costs Contract With Customer, Liability, Transaction Costs Schedule of Anti-Dilutive Securities Not Considered in Diluted Net Loss Per Common Share Calculation Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Products and Services [Domain] Product and Service [Domain] Other Performance Measure, Amount Other Performance Measure, Amount Proceeds from the sale of future royalties, net of issuance costs Proceeds from Debt, Net of Issuance Costs Gross To Net Sales Accrual And Reserve Classification [Axis] Gross To Net Sales Accrual And Reserve Classification [Axis] Gross To Net Sales Accrual And Reserve Classification IBSRELA Product, IBSRELA [Member] Product, IBSRELA Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Schedule of Lease Costs Lease, Cost [Table Text Block] Inventory Increase (Decrease) in Inventories Unrealized gains (losses) on available-for-sale securities Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Research and development Research and Development Expense [Member] Investing activities Net Cash Provided by (Used in) Investing Activities [Abstract] Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Antidilutive securities excluded from computation of earnings per share (in shares) Anti-dilutive securities not included in computation of diluted net loss per share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Award Type [Axis] Award Type [Axis] Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Abstract] Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Plan Name [Domain] Plan Name [Domain] Cost of goods sold: Cost of Goods and Services Sold [Abstract] Document Quarterly Report Document Quarterly Report Purchase price (in dollars per share) Share Based Compensation Arrangement by Share Based Payment Award, Purchased Price of Share Represents the purchase price per share of shares issued to employees under the plan. Interest expense Interest Expense AmerisourceBergen Drug Corporation AmerisourceBergen Drug Corporation [Member] AmerisourceBergen Drug Corporation Potential development and commercialization milestones Collaborative Arrangement, Potential Development And Commercialization Milestones Represents the amount of future development and commercialization milestone under collaborative arrangements. Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Right-of-use assets obtained in exchange for lease obligations Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Stockholders' Equity Note [Abstract] Stockholders' Equity Note [Abstract] Trading Arrangement: Trading Arrangement [Axis] Imputed interest expenses Lessee, Operating Lease, Liability, Undiscounted Excess Amount Use of Estimates Use of Estimates, Policy [Policy Text Block] PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Long-term Debt, Type [Domain] Long-Term Debt, Type [Domain] Entity File Number Entity File Number Loss Contingencies [Table] Loss Contingencies [Table] Lease Arrangements [Axis] Lease Arrangements [Axis] Lease Arrangements Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Current portion of operating lease liability Current portion of lease liabilities Less: Current portion of operating lease liability Operating Lease, Liability, Current Licensing revenue License License [Member] Allowance for credit loss on available for-sale debt securities Debt Securities, Available-for-Sale, Allowance for Credit Loss Issuance of common stock under employee stock purchase plan (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Gross To Net Sales Accrual And Reserve Classification [Domain] Gross To Net Sales Accrual And Reserve Classification [Domain] Gross To Net Sales Accrual And Reserve Classification [Domain] Proceeds from maturities and redemptions of investments Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale Entity Shell Company Entity Shell Company 2026 Lessee, Operating Lease, Liability, to be Paid, Year Three Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Restatement Determination Date Restatement Determination Date Secured Overnight Financing Rate (SOFR) Secured Overnight Financing Rate (SOFR) [Member] Secured Overnight Financing Rate (SOFR) Number of defendants Loss Contingency, Number of Defendants Counterparty Name [Domain] Counterparty Name [Domain] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash and cash equivalents at beginning of period Cash and cash equivalents at end of period Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents Asset Class [Axis] Asset Class [Axis] 2025 Lessee, Operating Lease, Liability, to be Paid, Year Two 2022 Term Loan Term Loan 2022 [Member] Term Loan 2022 Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Loan Agreement Loans Payable [Member] Denominator: Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Operating lease expense Operating Lease, Cost Common stock, shares issued (in shares) Common Stock, Shares, Issued Schedule of Restricted Stock Units Activity Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Vested (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Closing fee percentage Line of Credit Facility, Commitment Fee Percentage Deferred revenue Beginning balance Ending balance Contract with Customer, Liability, Current Security Exchange Name Security Exchange Name Long-term debt Long-Term Debt Assets, fair value Assets, Fair Value Disclosure Selling, general and administrative Selling, General and Administrative Expense Accumulated other comprehensive loss Accumulated Other Comprehensive Income (Loss), Net of Tax Collaboration and Licensing Agreements Collaborative Arrangement Disclosure [Text Block] Stock option grants Options to purchase common stock Employee Stock Option [Member] Derivative Liabilities Derivative Instruments and Hedging Activities Disclosure [Text Block] Common stock Common Class A [Member] Average Remaining Vesting Period (Years) Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Total operating expenses Costs and Expenses Maximum Maximum [Member] Comprehensive income (loss) Comprehensive Income (Loss), Net of Tax, Attributable to Parent Unrecognized Compensation Expense Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Document Type Document Type Long-term debt, net of current portion Loans Payable, Noncurrent Tabular List, Table Tabular List [Table Text Block] Entity Address, Address Line One Entity Address, Address Line One Prepaid commercial manufacturing Prepaid Commercial Manufacturing, Current Prepaid Commercial Manufacturing, Current Entity Address, Address Line Two Entity Address, Address Line Two Accrued expenses and other current liabilities Accrued Liabilities and Other Liabilities Subsequent Event [Table] Subsequent Event [Table] Equity Incentive Plans Share-Based Payment Arrangement [Text Block] Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Other, net Other Noncash Income (Expense) Weighted-Average Exercise Price per Share Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Subsequent event Subsequent Event [Member] Derivative [Table] Derivative [Table] Customer Customer Concentration Risk [Member] Variable Rate [Axis] Variable Rate [Axis] Cash Cash [Member] Income Statement [Abstract] Income Statement [Abstract] Prepayment premium (as percent) Debt Instrument, Prepayment Fee, Percentage The percentage of fee payable on prepayment of debt. Issuance of common stock in at the market offering (in shares) Stock Issued During Period, Shares, New Issues Options forfeited or canceled (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Title of 12(b) Security Title of 12(b) Security Short-term securities, contractual maturities maximum (in years) Available-For-Sale Securities, Debt Securities, Current, Contractual Maturities, Maximum Available-For-Sale Securities, Debt Securities, Current, Contractual Maturities, Maximum Amounts invoiced as prepayments for product supply Contract With Customer, Liability, Revenue Invoiced As Prepayments For Product Supply, Noncurrent Contract With Customer, Liability, Revenue Invoiced As Prepayments For Product Supply, Noncurrent Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Short-term investments: Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract] Sublease income Sublease Income Threshold percentage of net sales for tiered royalties Threshold Percentage of Sales For Tiered Royalties Represents the threshold percentage of net sales for tiered royalties. Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Numerator: Net Income (Loss) Attributable to Parent [Abstract] Outstanding balance, beginning (in dollars per share) Outstanding balance, ending (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Share-based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Abstract] Entity Tax Identification Number Entity Tax Identification Number 2023 Open Market Sales Agreement Open Market Sales Agreement 2023, At The Market Offering [Member] Open Market Sales Agreement 2023, At The Market Offering Exit fee, term (in years) Loan Agreement, Exit Fee, Term Loan Agreement, Exit Fee, Term Additional details Lessee, Operating Lease, Description [Abstract] Total Inventory, Net Statistical Measurement [Axis] Statistical Measurement [Axis] Inventory, non-current Inventory, non-current Inventory, Noncurrent Financial Instrument [Axis] Financial Instrument [Axis] Entity Interactive Data Current Entity Interactive Data Current Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Fosun Pharma Shanghai Fosun Pharmaceutical Industrial Development [Member] Represents Shanghai Fosun Pharmaceutical Industrial Development. Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-Sale [Table] Reclassify amounts to be recognized in the next twelve months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Contract With Customer, Liability, Revenue To Be Recognized In Next Twelve Months Total Shareholder Return Amount Total Shareholder Return Amount Product sales, net Product [Member] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Knight Agreement License Agreement Development Commercialization Distribution In Canada [Member] Agreement for the development, commercialization and distribution fo tenapanor in Canada. The Knight Agreement. Supplementary disclosure of non-cash activities: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Inventory Disclosure [Abstract] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Additional uncommitted capital Line Of Credit Facility, Accordion Feature, Additional Uncommitted Capital Line Of Credit Facility, Accordion Feature, Additional Uncommitted Capital Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit) Measure: Measure [Axis] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Name Outstanding Recovery, Individual Name Term loan face amount Debt Instrument, Face Amount Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Current assets: Assets, Current [Abstract] Leases [Abstract] Leases [Abstract] Entity Address, State or Province Entity Address, State or Province Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Counterparty Name [Axis] Counterparty Name [Axis] ESPP ESPP shares issuable Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Operating activities Net Cash Provided by (Used in) Operating Activities [Abstract] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Cash paid for operating lease Operating Lease, Payments Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Weighted-average sales price per share (in dollars per share) Sale Of Stock, Weighted-Average Price Per Share Sale Of Stock, Weighted-Average Price Per Share Operating lease, impairment loss Operating Lease, Impairment Loss Non-cash interest expense related to the sale of future royalties Amortization of the deferred royalty obligation Amortization of Advance Royalty PEO PEO [Member] Aggregate cost of revenue recognized Cost Of Revenue, Aggregate Amount Recognized Cost of revenue, aggregate amount recognized. AZ Termination Agreement AstraZeneca Termination Agreement [Member] AstraZeneca Termination Agreement Beginning balance (in shares) Ending balance (in shares) Shares, Outstanding Upfront payment received Proceeds from License Fees Received Asset Class [Domain] Asset Class [Domain] Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Sale of Stock [Axis] Sale of Stock [Axis] Facility, Fremont California Facility, Fremont California [Member] Facility, Fremont California Class of Stock [Domain] Class of Stock [Domain] Net cash (used in) provided by investing activities Net Cash Provided by (Used in) Investing Activities Customer [Domain] Customer [Domain] Schedule of Current Inventory Schedule of Inventory, Current [Table Text Block] Number of Shares Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Debt Instrument [Axis] Debt Instrument [Axis] Investment in continuous unrealized loss position for more than one year Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount Total operating lease liabilities Total operating lease liabilities Operating Lease, Liability Schedule of Future Debt Payment Obligations Schedule of Maturities of Long-Term Debt [Table Text Block] Total liabilities Liabilities Percentage of non-royalty revenue Percentage Of Non-Royalty Revenue Represents percentage of non-royalty revenue. Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Stock-based Compensation [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Accumulated Other Comprehensive Income AOCI Attributable to Parent [Member] Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Measurement Frequency [Domain] Measurement Frequency [Domain] All Executive Categories All Executive Categories [Member] Deferred revenue, non-current Beginning balance Ending balance Contract with Customer, Liability, Noncurrent Title of Individual [Axis] Title of Individual [Axis] Non-Rule 10b5-1 Arrangement Adopted Non-Rule 10b5-1 Arrangement Adopted [Flag] Plan Name [Axis] Plan Name [Axis] Debt Disclosure [Abstract] Debt Disclosure [Abstract] Right-of-use assets and lease liabilities Assets and Liabilities, Lessee [Abstract] Product supply revenue Product Supply Revenue [Member] Product Supply Revenue Earnings Per Share [Abstract] Earnings Per Share [Abstract] Subsequent Event [Line Items] Subsequent Event [Line Items] Exit fee (as percent) Exit Fee, Percentage Exit Fee, Percentage Common stock, $0.0001 par value; 500,000,000 shares and 300,000,000 shares authorized; 232,133,132 and 198,575,016 shares issued and outstanding as of September 30, 2023 and December 31, 2022, respectively. Common Stock, Value, Issued Total of gross proceeds Equity Sales Agreement, Proceeds From Shares Issued Since Inception Equity Sales Agreement, Proceeds From Shares Issued Since Inception Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Non-cash lease expense Operating Lease, Right-of-Use Asset, Periodic Reduction Commission on sale of stock per agreement (as percent) Stock Issuance Cost, Commission, Percent Stock Issuance Cost, Commission, Percent Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] Total current assets Assets, Current Schedule of Revenue from Customers as a Percentage of Total Product Revenue, Net Schedules of Concentration of Risk, by Risk Factor [Table Text Block] Revenue from Contract with Customer [Abstract] All Individuals All Individuals [Member] Supplementary disclosure of cash flow information: Supplemental Cash Flow Information [Abstract] Litigation Case [Domain] Litigation Case [Domain] Proceeds from the sale of future royalties, net of issuance costs Proceeds From Sale Of Future Royalties, Net Of Issuance Costs Proceeds From Sale Of Future Royalties, Net Of Issuance Costs Entity Filer Category Entity Filer Category Proceeds from 2022 Loan, net of issuance costs Proceeds from Issuance of Secured Debt Non-PEO NEO Average Total Compensation Amount Non-PEO NEO Average Total Compensation Amount Final fee due upon maturity, acceleration, prepayment, or termination (as percent) Debt Instrument, Fee Due Upon Maturity, Acceleration, Prepayment, Termination, Percentage Debt Instrument, Fee Due Upon Maturity, Acceleration, Prepayment, Termination, Percentage Statement [Table] Statement [Table] AstraZeneca Astrazeneca [Member] Represents information pertaining to AstraZeneca. Current Fiscal Year End Date Current Fiscal Year End Date Fair value analysis, percentage change in probability of occurrence Fair Value Sensitivity Analysis, Change In Probability Of Occurrence, Percentage Fair Value Sensitivity Analysis, Change In Probability Of Occurrence, Percentage Proceeds from milestone payments Revenue, Remaining Performance Obligation, Variable Consideration Amount Revenue, Remaining Performance Obligation, Variable Consideration Amount Number of payment tranches for fee receivable for reduction in royalty rate Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate, Number Of Payment Tranches Collaborative Arrangement, Fee Receivable For Reduction In Royalty Rate, Number Of Payment Tranches PEO Name PEO Name Concentration risk (as percent) Concentration Risk, Percentage Estimated fair value Beginning balance Ending balance Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Asset-backed securities Asset-backed securities Asset-Backed Securities [Member] Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Additional committed capital Line Of Credit Facility, Accordion Feature, Additional Committed Capital Line Of Credit Facility, Accordion Feature, Additional Committed Capital Class of Stock [Axis] Class of Stock [Axis] 2018 Term Loan Term Loan 2018 [Member] Term Loan 2018 Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] Short-term investments Debt Securities, Available-for-Sale, Current Less: Unaccreted value of final fee Debt Instrument, Fee Amount After second anniversary to maturity date Debt Instrument, Redemption, Period Three [Member] Fosun Agreement License Agreement Development Commercialization Distribution In China [Member] Agreement for the development, commercialization and distribution of tenapanor in China. The Fosun Agreement. Depreciation and amortization expense Depreciation, Depletion and Amortization Issuance of derivative in connection with issuance of loan payable Derivative Issued Derivative Issued Non-Current Change In Contract With Customer Liability, Noncurrent, Rollforward [Roll Forward] Change In Contract With Customer Liability, Noncurrent, Rollforward Schedule of Chargebacks, Discounts and Reserve Balances Schedule Of Gross To Net Sales Accruals [Table Text Block] Schedule Of Gross To Net Sales Accruals Interest rate (as percent) Debt Instrument, Interest Rate, Stated Percentage Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] Accrued compensation and benefits Increase (Decrease) in Employee Related Liabilities Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Term Loan A Term Loan 2022 A [Member] Term Loan 2022 A Exit fee, net product revenue threshold Loan Agreement, Exit Fee, Net Product Revenue Threshold Metric, Trailing Six Month Basis, Minimum Loan Agreement, Exit Fee, Net Product Revenue Threshold Metric, Trailing Six Month Basis, Minimum Total stockholders’ equity Beginning balance Ending balance Equity, Attributable to Parent Commercial paper Commercial Paper [Member] Cash and short-term investments Total cash equivalents and investments, Fair Value Investments and Cash 2017 KKC Agreement License Agreement Development Commercialization Distribution In Japan [Member] Agreement for the development, commercialization and distribution of tenapanor in Japan. The 2017 KKC Agreement. Deferred revenue Increase (Decrease) in Deferred Revenue Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Aggregate amount paid Payments Of Uncharged License Fees, Aggregate Amount Paid Payments of uncharged license fees, aggregate amount paid. Subsequent Events [Abstract] Subsequent Events [Abstract] Income (loss) before provision for income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Fair Value Measurements Fair Value Measurement, Policy [Policy Text Block] Number of lawsuits Loss Contingency, New Claims Filed, Number Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Level 2 Fair Value, Inputs, Level 2 [Member] 2021 Open Market Sales Agreement Open Market Sales Agreement 2021, At The Market Offering [Member] Open Market Sales Agreement 2021, At The Market Offering Entity Emerging Growth Company Entity Emerging Growth Company Finished goods Inventory, Finished Goods, Gross Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] Document Fiscal Period Focus Document Fiscal Period Focus Potential development milestones Collaborative Arrangement, Potential Development Milestones Collaborative Arrangement, Potential Development Milestones 2024 Lessee, Operating Lease, Liability, to be Paid, Year One Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Title Trading Arrangement, Individual Title Options outstanding balance, beginning (in dollars per share) Options outstanding balance, ending (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Stock-based compensation Share-Based Payment Arrangement, Noncash Expense Common Stock Common Stock [Member] Provisions Contract With Customer, Gross To Net Sales, Provisions Contract With Customer, Gross To Net Sales, Provisions Individual: Individual [Axis] Lease Arrangements [Domain] Lease Arrangements [Domain] Lease Arrangements [Domain] City Area Code City Area Code Entity Address, Postal Zip Code Entity Address, Postal Zip Code Net Income (Loss) Per Share Earnings Per Share [Text Block] Product and Service [Axis] Product and Service [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Payments for 2018 Loan, net of costs Repayments of Secured Debt Schedule of Changes in Fair Value of Derivative Liability Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Document Fiscal Year Focus Document Fiscal Year Focus Geographical [Domain] Geographical [Domain] Minimum Minimum [Member] Property and equipment, net Property, Plant and Equipment, Net Organization and Basis of Presentation Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Healthcare royalty partners IV, L.P HealthCare Royalty Partners IV, L.P [Member] HealthCare Royalty Partners IV, L.P Schedule of Stock Option Activity Share-Based Payment Arrangement, Option, Activity [Table Text Block] Exercise Price Award Exercise Price Office space area (in sq.ft) Area of Real Estate Property Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Assets Assets [Abstract] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Liabilities, fair value Liabilities, Fair Value Disclosure Operating lease liabilities Increase (Decrease) in Operating Lease Liability Other cost of revenue Product and Service, Other [Member] Cash paid for income taxes Income Taxes Paid, Net Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities 2022 Exit Fee addition at fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Purchases Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Contingencies Commitments and Contingencies Disclosure [Text Block] Accumulated Deficit Retained Earnings [Member] Schedule of Stock-Based Compensation Expense Recognized Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Total liabilities and stockholders’ equity Liabilities and Equity Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Other assets Other Assets, Noncurrent Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Net income (loss) per common stock - basic (in dollars per share) Net income (loss) per share of common stock - basic (in dollars per share) Earnings Per Share, Basic Right-of-use assets Right-of-use assets Operating Lease, Right-of-Use Asset Schedule of Long-term Debt Instruments [Table] Schedule of Long-Term Debt Instruments [Table] Issuance of common stock under employee stock purchase plan Stock Issued During Period, Value, Employee Stock Purchase Plan Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] Sale of Stock [Domain] Sale of Stock [Domain] Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Knight Knight Therapeutics Inc [Member] Represents information pertaining to Knight Therapeutics Inc. Remainder of 2023 Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year Arrangement Duration Trading Arrangement Duration Strezsak v. Ardelyx, Inc. Strezsak Versus Ardelyx, Inc. [Member] Strezsak Versus Ardelyx, Inc. Entity Address, City or Town Entity Address, City or Town Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Issuance of common stock for services Stock Issued BioRidge Pharma, LLC BioRidge Pharma, LLC [Member] BioRidge Pharma, LLC Issuance of common stock for services Stock Issued During Period, Value, Issued for Services Document Transition Report Document Transition Report Award Timing Predetermined Award Timing Predetermined [Flag] Termination Date Trading Arrangement Termination Date Collaboration and Licensing Agreements Collaboration and Licensing Agreements n/a Accounts payable Increase (Decrease) in Accounts Payable Common stock, shares authorized (in shares) Common Stock, Shares Authorized Fair Value Debt Securities, Available-for-Sale Raw materials Inventory, Raw Materials, Gross Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Derivative Instrument [Axis] Derivative Instrument [Axis] Current Change In Contract With Customer Liability, Current, Rollforward [Roll Forward] Change In Contract With Customer Liability, Current, Rollforward Principal outstanding Total repayment obligations Long-Term Debt, Gross Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Liability Class [Axis] Liability Class [Axis] All Trading Arrangements All Trading Arrangements [Member] All Adjustments to Compensation All Adjustments to Compensation [Member] Derivative [Line Items] Derivative [Line Items] Award Timing Disclosures [Line Items] Title of Individual [Domain] Title of Individual [Domain] Floor Rate Secured Overnight Financing Rate (SOFR) Floor Rate [Member] Secured Overnight Financing Rate (SOFR) Floor Rate Deferred royalty obligation related to the sale of future royalties Deferred Royalty Obligation, Noncurrent Deferred Royalty Obligation, Noncurrent Compensation Amount Outstanding Recovery Compensation Amount Fair value analysis, effect on fair value based on 10% change in probability of occurrence Fair Value Sensitivity Analysis, Ten Percent Change In Probability Of Occurrence, Effect On Valuation Fair Value Sensitivity Analysis, Ten Percent Change In Probability Of Occurrence, Effect On Valuation Discounts and Chargebacks Contract With Customer, Discounts And Chargebacks [Member] Contract With Customer, Discounts And Chargebacks Term Loan C Term Loan 2022 C [Member] Term Loan 2022 C Forfeited (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Subsequent Event Type [Axis] Subsequent Event Type [Axis] Reclassify amounts to be recognized in the next twelve months Contract With Customer, Liability, Decrease In Revenue, To Be Recognized In Next Twelve Months Contract With Customer, Liability, Decrease In Revenue, To Be Recognized In Next Twelve Months Derivative liabilities for exit fees Exit Fee derivative liability Derivative Financial Instruments, Liabilities [Member] Gain on sale of equipment Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property Decrease for revenue recognized for product supply Contract With Customer, Liability, Revenue Recognized Cash Not Received, Noncurrent Contract With Customer, Liability, Revenue Recognized Cash Not Received, Noncurrent Maximum potential payment per agreement Collaborative Arrangement, Potential Payment Per Termination Agreement, Maximum Collaborative Arrangement, Potential Payment Per Termination Agreement, Maximum Upfront license fees Collaboration And Licensing Agreements, Upfront License Fees Collaboration And Licensing Agreements, Upfront License Fees Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Options forfeited or canceled (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Work in process Inventory, Work in Process, Gross Forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Rebates, Wholesaler and GPO Fees Contract With Customer, Rebates [Member] Contract With Customer, Rebates Debt Instrument, Redemption, Period [Domain] Debt Instrument, Redemption, Period [Domain] Insider Trading Arrangements [Line Items] Cash and cash equivalents: Cash and Cash Equivalents, at Carrying Value [Abstract] Prior to first anniversary of closing date Debt Instrument, Redemption, Period One [Member] Future obligation upon loan funding or other events Loan Agreement, Future Obligation Upon Funding Or Other Events Loan Agreement, Future Obligation Upon Funding Or Other Events Entity Registrant Name Entity Registrant Name Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Award Timing Method Award Timing Method [Text Block] Schedule of Total Unrecognized Stock-Based Compensation Expense, Net of Estimated Forfeitures Share-Based Payment Arrangement, Nonvested Award, Cost [Table Text Block] Adjustment to Compensation, Amount Adjustment to Compensation Amount Proceeds from sale of property and equipment Proceeds from Sale of Property, Plant, and Equipment Document Period End Date Document Period End Date Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Adoption Date Trading Arrangement Adoption Date Schedule of Fair Value of Financial Assets and Liabilities Measured on a Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Options exercisable (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Credits/payments Contract With Customer, Gross To Credits Or Deductions Issued Contract With Customer, Gross To Credits Or Deductions Issued Entity Central Index Key Entity Central Index Key Contingent liabilities Loss Contingency Accrual Liabilities: Liabilities, Fair Value Disclosure [Abstract] Stock-based compensation expense Share-Based Payment Arrangement, Expense Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] Provision for income taxes Income Tax Expense (Benefit) Total cash equivalents and investments, Gross Unrealized Gains Cash Cash Equivalents And Investments Gross Unrealized Gains Cash, cash equivalents and investments gross unrealized gains. Accrued compensation and benefits Employee-related Liabilities, Current Fair Value Measurements Fair Value Disclosures [Text Block] Proceeds from royalties received Proceeds from Royalties Received Amortization, effective interest rate (as percent) Contract With Customer, Liability, Amortization, Effective Interest Rate, Percent Contract With Customer, Liability, Amortization, Effective Interest Rate, Percent Number of segments Number of Operating Segments Name Trading Arrangement, Individual Name Cash and Cash Equivalents [Abstract] Cash and Cash Equivalents [Abstract] Loan agreement covenant, cash and cash equivalents as percentage of outstanding loan balance, minimum Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Minimum Loan Agreement, Covenant, Cash And Cash Equivalents As Percentage Of Outstanding Loan Balance, Minimum Prepaid commercial manufacturing Increase (Decrease) In Prepaid Commercial Manufacturing Expense Increase (Decrease) In Prepaid Commercial Manufacturing Expense Issuance of common stock in at the market offering Stock Issued During Period, Value, New Issues Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-Sale [Line Items] Inventory Inventory Disclosure [Text Block] Weighted-average remaining life (years) Operating Lease, Weighted Average Remaining Lease Term Total revenues Revenue Revenue from Contract with Customer, Excluding Assessed Tax Term Loan B Term Loan 2022 B [Member] Term Loan 2022 B Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Justin Renz [Member] Justin Renz Long-term Debt, Type [Axis] Long-Term Debt, Type [Axis] Amendment Flag Amendment Flag Money market funds Money market funds Money Market Funds [Member] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Cash and cash equivalents Fair Value Cash and Cash Equivalents, at Carrying Value Weighted-average discount rate Operating Lease, Weighted Average Discount Rate, Percent Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Assets: Assets, Fair Value Disclosure [Abstract] Total cash equivalents and investments, Amortized Cost Investments And Cash, Amortized Cost Investments And Cash, Amortized Cost Floating per annum rate (as percent) Debt Instrument, Basis Spread on Variable Rate Issuance of common stock for services (in shares) Stock Issued During Period, Shares, Issued for Services Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] McKesson Corporation McKesson Corporation [Member] McKesson Corporation Shares used in computing net income (loss) per share - diluted (in shares) Weighted average common shares outstanding - diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Go v. Raab Go Versus Raab [Member] Go Versus Raab Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Schedule of Deferred Revenue Balances Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block] Deferred Royalty Obligation Related To The Sale Of Future Royalties Asset Retirement Obligation Disclosure [Text Block] Operating expenses: Operating Expenses [Abstract] Gross product revenue Revenue, Product and Service Benchmark [Member] Product Revenue, Net Revenue from Contract with Customer [Text Block] Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Company Selected Measure Amount Company Selected Measure Amount Additional paid-in capital Additional Paid in Capital, Common Stock Additional Paid-In Capital Additional Paid-in Capital [Member] Lease costs Lease, Cost [Abstract] Total assets Assets Name Awards Close in Time to MNPI Disclosures, Individual Name Gross-to-net sales accruals and reserves Contract With Customer, Gross To Net Sales Accrual [Roll Forward] Contract With Customer, Gross To Net Sales Accrual Contingencies [Line Items] Loss Contingencies [Line Items] Cover [Abstract] Cover [Abstract] Commercial paper Commercial Paper, Not Included with Cash and Cash Equivalents [Member] Subsequent Events Subsequent Events [Text Block] Stock-based compensation APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Recurring Fair Value, Recurring [Member] Other liabilities, non-current Other Liabilities, Noncurrent Vested (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Non-NEOs Non-NEOs [Member] Total undiscounted operating lease payments Lessee, Operating Lease, Liability, to be Paid Term Loan D Term Loan 2022 D [Member] Term Loan 2022 D Payment to be received Revenue, Remaining Performance Obligation, Amount Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Line Items] Net decrease in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Financing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Non-PEO NEO Non-PEO NEO [Member] Equity Component [Domain] Equity Component [Domain] Adjustment to Compensation: Adjustment to Compensation [Axis] 2018 Exit Fee Exit Fee 2018 [Member] Exit Fee 2018 Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Debt Instrument [Line Items] Debt Instrument [Line Items] Shares used in computing net income (loss) per share - basic (in shares) Weighted average common shares outstanding - basic (in shares) Weighted Average Number of Shares Outstanding, Basic Entity Current Reporting Status Entity Current Reporting Status Concentration Risk Type [Domain] Concentration Risk Type [Domain] Income (loss) from operations Operating Income (Loss) Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] After first anniversary through second anniversary of closing date Debt Instrument, Redemption, Period Two [Member] METiS Therapeutics Inc METiS Therapeutics Inc [Member] METiS Therapeutics Inc Revenues: Revenues [Abstract] 2022 Exit Fee Exit Fee 2022 [Member] Exit Fee 2022 Cost of revenue Cost of Revenue Cash, Cash Equivalents and Investments Cash, Cash Equivalents, and Short-Term Investments [Text Block] Comprehensive income (loss): Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Proceeds from issuance of common stock under equity incentive and stock purchase plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Statement [Line Items] Statement [Line Items] Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Maximum aggregate offering price Maximum Aggregate Offering Price Amount of maximum aggregate offering price.